Aeroallergens

Marcel Dekker Inc. 270Madison Avimiie, New Yori New Yoik 10016 

Cysteine protease Aspartate protease Metalloprotease Carbohydrases 

Enzyme inhibitors Transport proteins Regulatory proteins 

Egg white lysozyme, mite group 4 amylase, plant, fungal, bacterial and mammalian amylases, cellulase, xylanase, fungal pectinase, fungal glucoamylase. Cry j 2  

Asp f 1, group 5 grass pollen allergens, group 1 tree pollen allergens 

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Sampson HA, Mendelson L, Rosen JP Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992 327 380-384. De Bilderling G, Mathot M, Agustsson S, Tuerlinckx D. Jamart J. Bodart E Early skin sensitization to aeroallergens. Clin Exp Allergy 2008 38 643-648. 

Working with these rodent models, we have accumulated evidence that indicate local DC (airway mucosal dendritic cells, AMDC) are ideally positioned to drive activation of the aeroallergen-specific Th cells which are responsible for the LPR component of asthma exacerbations (fig. 1). 

Role of Adaptive Immune Responses in Atopic Dermatitis Involving IgE Responses In about 80% of adult patients with atopic dermatitis, the disease is associated with increased serum IgE levels, sensitization against aeroallergens... 

Specific immunotherapy (SIT) with aeroallergens directly addresses adaptive mechanism in hypersensitivity reactions. A meta-analysis of SIT studies revealed positive effects of subcutaneous... 

Araujo MI, Lopes AA, Medeiros M, et al Inverse association between skin response to aeroallergen and Schistosoma mansoni infection. Int Arch Allergy Immunol 2000 123 145-148. 

Mahakit. Aeroallergen sensitivity of Thai patients with allergic rhinitis. Asian Pac J Allergy Immunol 1997 15(4) 183-185. 

Silvestri M, Rossi GA, Cozzani S, Pulvirenti G, Fasce L Age-dependent tendency to become sensitized to other classes of aeroallergens in atopic asthmatic children. Ann Allergy Asthma Immunol 1999 83 335-340. 

Omalizumab Xolair Asthma (positive skin test or in-vitro reactivity to a perennial aeroallergen) 2003 (not by EMEA)C)... 

To date, the APT with foods is not well standardized and different methods in preparing the test materials are likely to cause controversial results. Most studies with foods have been performed with cow s milk, hen s egg, and wheat. The fresh foods should be preferred over commercial extracts for testing. The APT with foods like cow s milk or hen s egg has been studied in infants and children since food allergy plays a role especially in this age group, whereas aeroallergens (house dust mite) have been studied more intensively in adults (Turnjamaa et al., 2006). 

Taylor, A.V., Swanson, M.C., Jones, R.T., Vives, R., Rodriguez, J., Yunginger, J.W., Crespo, J.F. 2000. Detection and quantitation of raw fish aeroallergens from an open-air fish market. Journal of Allergy and Clinical Immunology 105(1) 166—169. 

Monsalve, R.I., Gonzalez de la Pena, M.A., Lopez-Otin, C. et al. 1997. Detection, isolation and complete amino acid sequence of an aeroallergenic protein from rapeseed flour. Clin Exp Allergy 27 833-841. 

O Hollaren MX, Yunginger JW, Offord KP, Somers MJ, O Connell EJ, Ballard DJ, Sachs MI Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 1991 324 359-363. 

The true workhorses of aeroallergen samplers however, are all impactors (table 1). The rotorod, the Burkard (Hirst-type) spore trap, the personal Burkard, the Air-O-Cell, and the Andersen (several types) are all impactor... 

Epton MJ, Martin IR, Graham P, Healy PE, Smith H, Balasubramaniam R, Harvey IC, Fountain DW, Hedley J, Town GI Climate and aeroallergen levels in asthma A 12-month prospective study. Thorax 1997 52 528-534. 

Ellis MH, Gallup J Aeroallergens of southern California. Irrrmrmol Allergy Clin North Am 1989 9 365-380. 

Fischer B, Yawalkar N, Brander KA, Kchler WJ, Helbling A Coprinus comatus (shaggy cap) is a potential source of aeroallergen that may provoke atopic dermatitis. J Allergy Clin Immimol 1999 104 836-841. 

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