Adverse, drug reactions pediatrics

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Ross CJD, Visscher H, Rassekh SR et al (2011) Pharmacogenomics of serious adverse drug reactions in pediatric oncology. J Popul Ther Clin Pharmacol 18 el34-el51... 

Rieder M (2012) New ways to detect adverse drug reactions in pediatrics. Pediatr Clin North Am 59 1071-1092... 

Kenneh AB (2004) Adverse drug reactions in children part I. Pediatr Nurs 16 32-35... 

Davis M, Williams R (1978) Drugs and the liver. In Davies DM (ed) Textbook of adverse drug reactions. Oxford University Press, Oxford de Week AL (1971) Immunological effects of aspirin anhydride, a contaminant of commercial acetylsalicylic acid preparations. Int Arch Allergy Appl Immunol 41 393-418 Duberstein JL, Kaufman DM (1972) Heroin intoxication in adolescents. Pediatrics 50 746-753... 

Smith JW, Johnson JE, Cluff LE (1966) Studies on the epidemiology of adverse drug reactions. II. An evaluation of penicillin allergy. N Engl J Med 274 998 Sokoloff B (1977) Ampicillin rashes. Pediatrics 59 637... 

Adverse reactions to drugs differ in both type and incidence in the pediatric population. Because of immature metabolic pathways, infants and children may have different metabolic patterns than adults. This at least partially explains why neonates require lower theophylline serum concentrations for the treatment of neonatal apnea and why the incidence of hepatotoxi-city following acetaminophen overdose is much lower in young children than in adults [44,45]. Antibiotic adverse effects unique to the pediatric population may... 

The American Academy of Pediatrics recommends that doxycycline not be used in children less than 9 years of age because of retarded skeletal growth in infants and discolored teeth in infants and toddlers (Inglesby et al., 2002). Because of the serious nature of anthrax infection, however, Inglesby and colleagues (2002) recommend that doxycycline, instead of ciprofloxacin, be used in children if antibiotic susceptibility testing, exhaustion of drug supplies, or adverse reactions preclude the use of ciprofloxacin. 

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