Adverse drug reactions detection

In general, the detection of adverse drug reactions early in the drug discovery process is becoming commonplace. So-called liability panels of receptors, hERG channel activity, and cytochrome enzymes are utilized to identify... 

Approximately 30-40% of patients will not respond to a given antidepressant and 60-75% may fail to achieve complete remission [16]. Consequently, in its least restricted definition, treatment resistance could be detected in the majority of depressed patients under treatment. Moreover, prior treatment failure negatively influences the response to subsequent antidepressant treatment, decreasing the odds of treatment response by a factor of 15-20% for each failed treatment [17]. The delayed onset of symptom relief (which takes three to eight weeks to occur) and the presence of adverse drug reactions contribute significantly to low treatment compliance. 

Wilkins, M. R., What do we want from proteomics in the detection and avoidance of adverse drug reactions, Toxicol. Lett., 127, 245, 2002. 

Hutchinson, T.A. (1992). Causality assessments of suspected adverse drug reactions. In Detection of New Adverse Drug Reactions (Stephens, M.B.D., Ed.). Macmillan, Press, London. 

Jones JK. Regulatory Use of Adverse Reactions. In Detection and Prevention of Adverse Drug Reactions. 1983 International Symposium, Stockholm, Skan-dia International Symposia, Ahnquist and Wiksall International, Stockholm, 1984 203-14. 

WHO. Safety of medicine. A guide to detecting and reporting adverse drug reactions. Geneva World Health Organization 2002. (WHO/EDM/QSM/2002.2.)... 

Fosters the safe and proper use of medicines through the detection, evaluation, understanding, and prevention of adverse drug reactions or any other drug-related problems. 

Corrigan, O.P., A risky business tire detection of adverse drug reactions in clinical trials and postmarketing exercises, Soc. Sci. Med., 55, 497, 2002. 

Detects and reports suspected adverse drug reactions accurately and in a timely manner. 

Schroeder DR. Statistics detecting a rare adverse drug reaction using spontaneous reports. Reg Anesth Pain Med 1998 23(suppl 2) I 83-1 89. 

Stephens M. Introduction. In Talbot J, Waller P, eds. Stephens detection of new adverse drug reactions. West Sussex, England John Wiley Sons, Ltd 2004. 

Specialized resources pertaining to ADRs and drug-induced diseases (e.g., Drug-Induced Diseases Prevention, Detection, and Management Meyler s Side Effects of Drugs Davies s Textbook of Adverse Drug Reactions)... 

Cor so DM, Pucino F, DeLeo JM, Calls KA, Gallelli JF. Development of a questionnaire for detecting potential adverse drug reactions. Ann Pharmacother 1992 26 890-6. 

A thorough study of the risk of myocarditis or cardiomyopathy in Australia detected 23 cases (mean age 36 years 20 men) out of 8000 patients treated with clozapine from January 1993 to March 1999 (absolute risk 0.29% relative risk about 1000-2000) (17). AH the accumulated data on previous reports of sudden death, myocarditis, or cardiac disease noted in connection with clozapine treatment were requested from the Adverse Drug Reactions... 

Eg bertsTC, Smulders M, de Koning FH, Meyboom RH, Leufkens HG. Can adverse drug reactions be detected earlier A comparison of reports by patients and professionals. Br Med J 1996 313 530-1. 

Strieker BH, Psaty BM. Detection, verification, and quantification of adverse drug reactions. Br Med J 2004 329(7456) 44-7. Thomsen HS, Marckmann P, Logager VB. Nephrogenic systemic fibrosis (NSF) a late adverse reaction to some of the gadolinium based contrast agents. Cancer Imaging 2007 7 130-7. 

Hughes AR, Brothers CH, Mosteller M, et al. Genetic association studies to detect adverse drug reactions Abacavir hypersensitivity as an example. Pharmacogenomics. 2009 10(2) 225-233. 

Abrutyn, Better Reporting of Adverse Drug Reactions Soffer, Practitioner s Role in Detection Rossi and Knapp, Discovery of New Adverse Drug Reactions. ... 

Soffer, A. The Practitioner s Role in Detection of Adverse Drug Reactions. Archives of Internal Medicine 145 (1985) 232-33. 

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