Adverse drug reactions patient reports

The nurse must use judgment about when adverse drug reactions are reported to the primary health care provider. Accurate observation and evaluation of the circumstances are essential the nurse should record all observations in the patient s record. If there is any question regarding the events that are occurring, the nurse can withhold the drug but must contact the primary health care provider. 

Drug reactions are potentially serious. The nurse should observe all patients for adverse drug reactions, drug idiosyncrasy, and evidence of drug tolerance (when applicable). It is important to report all drug reactions or any unusual drug effect to the primary health care provider. 

The nurse observes the patient closely for any adverse drug reactions, particularly signs and symptoms of a hypersensitivity reaction. It is important to report a... 

Monitoring and Managing Adverse Drug Reactions The nurse observes the patient at frequent intervals, especially during the first 48 hours of therapy. It is important to report to the primary health care provider the occurrence of any adverse reaction before the next dose of the drug is due The nurse should report serious adverse reactions, such as a severe hypersensitivity reaction, respiratory difficulty, severe diarrhea, or a decided drop in blood pressure, to the primary health care provider immediately because a serious adverse reaction may require emergency intervention. 

The nurse always listens, evaluates, and reports any complaints die patient may have certain complaints may be an early sign of an adverse drug reaction. The nurse should report all changes in die patient s condition and any new problems that occur (eg, nausea or diarrhea) as soon as possible. It is tiien up to the primary health care provider to decide if tiiese changes or... 

Continual cardiac monitoring assists the nurse in assessing the patient for adverse drug reactions. If the patient is acutely ill or is receiving one of these drugs par-enterally, the nurse measures and records the fluid intake and output. The primary health care provider may order subsequent laboratory tests to monitor the patient s progress for comparison with tests performed in the preadministration assessment, such as an ECG, renal and hepatic function tests, complete blood count, serum enzymes, and serum electrolytes. The nurse reports to the primary care provider any abnormalities or significant... 

Sulfasalazine is another DMARD often used in the treatment of RA. It is estimated that 20-30% of RA patients on SSZ report adverse drug reactions. Adverse drug events of SSZ are G1 and hematologic. 

Campbell JPM, Howie JGR. Involving the patient in reporting adverse drug reactions. J Roy Coll Gen Pract 1988 38 370-1. 

Sponsors are not required, as a matter of routine, to submit individual patient reports to the TGA of suspected adverse drug reactions occurring with use of the same product in another country, even if a trial is ongoing at Australian sites. However, the TGA requires that sponsors advise the Experimental Drugs Section of DSEB within 72 h of any significant safety issue which has arisen from an analysis of overseas reports or action with respect to safety taken by another country s regulatory agency. This advice must include the basis for such action. 

In a review of reports to the Australian Adverse Drugs Reactions Advisory Committee between 1985 and 2001 there were 48 cases of lactic acidosis with metformin (86). In 35 of the 48 cases known susceptibility factors were identified. The estimated frequency was one case of lactic acidosis in 30 000 patients taking metformin. The authors... 

In a multicenter, open, phase III study in 104 Korean patients there were eight adverse drug reactions in six patients taking pitavastatin and 19 adverse drug reactions in 12 patients taking simvastatin (4). However, there were no reports of serious reactions in either group. 

Diplopia may be an early sign of generalized drug-induced muscle dysfunction. Altogether, 71 cases of diplopia, possibly related to various HMG-CoA inhibitors, have been collected from adverse drug reactions-report-ing databases. The information was mostly too scanty to judge a causal relation, but improvement occurred in 33 on withdrawal, and two patients had positive rechallenge data (52). 

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