Adverse drug reactions INDEX

Adverse Drug Reactions Unit (Australia) http //www.health.gov.au/tga/adr/index.htm... 

Index of drugs this index provides a complete listing of all text references to a drug for which adverse effects, adverse reactions, and/or drug interactions are described. 

The print edition of this Reference Work contains two indexes, the Index of Drug Names and the Index of Adverse Reactions . Both indexes are print oriented and point at pages in the main text in which a reaction is discussed or a drug name used. 

Phenazone, commonly known as antipyrine, is still used therapeutically in some countries, although it is now used mainly as a marker of hepatic enzyme drug metabolizing activity. It is an old compound with little recent investigation, usually taken in combination with other analgesics, and an exact analysis of its adverse effects is impossible. Phenazone seems to have a low toxicity index, in correspondence with its weak anti-inflammatory effect. Allergic reactions are very rare (SEDA-6, 92) (SEDA-14, 92) (SEDA-16,108), but subjects undergoing the phenazone test should be informed of the potential risk. 

Certainly, most in vitro assays cannot predict (a) metabolite effects, (b) adverse effects associated by accumulation, and (c) drug actions at targets with mutations. Nevertheless, early safety-profiling assays have the power to detect trends toward certain adverse reactions and organ toxicity and to navigate drug discovery teams away from them. The major difficulty is estimating the impact of the data on the clinical performance determined by the human therapeutic index. 

Many adverse reactions are well known. Information about them can be found in patient information leaflets supplied with medicines, in the Monthly Index of Medical Specialties MIMS) or in the British National Formulary (BNF). However, not all patients will suffer all possible adverse reactions. Knowledge of family history can help predict who will suffer from adverse reactions. It is therefore good practice when taking a patient s history to ask about incidents of adverse reactions to drugs or allergies in the family. 

Index of adverse effects and reactions this index provides a listing of text references to which drugs cause adverse effects, adverse reactions, and drug interactions. 

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