Genetic factors adverse drug reactions

Age, disease states, genetics, gender, nutrition, multidrug therapy use, and herbal therapies use are patient-related factors that influence the likelihood of adverse drug reactions. 

In conclusion, there is increasing evidence to show that idiosyncratic adverse drug reactions are genetically determined. Identification of such factors is important, not... 

The susceptibility factors for rhabdo-myolysis have been examined from data held by the Swedish Adverse Drug Reactions Advisory Committee [21 ]. There were 338 cases of serious muscle toxicity, of whom 190 were classified as having had rhabdomyolysis on the basis of highly raised creatine kinase activities. Renal disease, unusually strenuous muscular activity, and high dosage statins were clear susceptibility factors. The likelihood of myopathy is increased in subjects with a genetic variant... 

Wilke RA, Lin DW, Roden DM, et al. Identifying genetic risk factors for serious adverse drug reactions current progress and challenges. Nat Rev Drug Discov. 2007 6 904-16. 

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