Advanced Strategies for Spatially Resolved Surface Design via Photochemical Methods

Chapter written by Anja S. Goldmann, Guillaume Delaitteie, Jan O. Mueller and Christopher Barner-Kowollik. 

Dyes and Chromophores in Polymer Science, First Edition. Edited by Jacques Lalevee and Jean-Ketre Fouassier. ISTE Ltd 2015. Published by ISTE Ltd and John Wiley Sons, Inc. 

In the study involving surface functionalization by photoenol chemistry, we introduced a novel 2-formyl-3-methylphenoxy (FMP) motif which we found more efficient than the 2-methylbenzophenone (at least in the conditions we used) [PAU 12b]. In particular, we demonstrated that complete cycloaddition could take place in minutes. Therefore, we aimed at bringing an FMP derivative onto surfaces in order to carry out patterning experiments. Again, we S5uithesized a silane derivative which we coated onto silicon wafers and assessed the success of the reaction by XPS and ToF-SIMS. The former confirmed the presence of the FMP moiety and the success of the photoinduced ftmctionalization of a bromine-containing maleimide which can act as a pol5mierization initiator as we will describe below. We also showed by ToF-SIMS that it is possible to use the photoenol method in the fiamework of peptide immobilization. 

1) IR point irradiation of the FMP-functionalized 3D structures in the presence of a biotin maleimide solution  

2) IR point irradiation with a benzylguanine-maleimide solution (benzylaguanine is the substrate for SNAP-tagged proteins [ENG 10, KEP 03, KIN 03])  

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Advanced Strategies for Spatially Resolved Surface Design via Photochemical Methods... 

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