Absorption, distribution ADME

ADME Absorption, distribution, metabolism, excretion FBVS Fragment-based virtual screening... 

ADME absorption/distribution/metabolism/elimination (excretion)... 

The genesis of in silico oral bioavailability predictions can be traced back to Lip-inski s Rule of Five and others qualitative attempts to describe drug-like molecules [13-15]. These processes are useful primarily as a qualitative tool in the early stage library design and in the candidate selection. Despite its large number of falsepositive results, Lipinski s Rule of Five has come into wide use as a qualitative tool to help the chemist design bioavailable compounds. It was concluded that compounds are most likely to have poor absorption when the molecular weight is >500, the calculated octan-l-ol/water partition coefficient (c log P) is >5, the number of H-bond donors is >5, and the number of H-bond acceptors is >10. Computation of these properties is now available as an ADME (absorption, distribution, metabolism, excretion) screen in commercial software such as Tsar (from Accelrys). The rule-of-5 should be seen as a qualitative, rather than quantitative, predictor of absorption and permeability [16, 17]. 

Pharmacokinetic/ ADME (absorption, distribution, metabolism, elimination) studies including bioanalytical method development... 

ACGIH American Conference of Governmental Industrial Hygienists ADME Absorption, Distribution, Metabolism, and Excretion AML acute myeloid leukemia... 

Nearly 15 years after Patched s speech, we still face the same problems that he highlighted. Medicinal chemists often synthesize a potent molecule and find later that it has poor exposure in vivo, and thus poor efficacy. Poor exposure can be caused by many different factors. Most of the factors affecting exposure are commonly known by acronym ADME - absorption, distribution, metabolism, and excretion. A fifth factor, solubility, is also very important and is commonly considered to be part of ADME. 

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