ADME Absorption, Distribution, Metabolism and

ACGIH American Conference of Governmental Industrial Hygienists ADME Absorption, Distribution, Metabolism, and Excretion AML acute myeloid leukemia... 

Nearly 15 years after Patched s speech, we still face the same problems that he highlighted. Medicinal chemists often synthesize a potent molecule and find later that it has poor exposure in vivo, and thus poor efficacy. Poor exposure can be caused by many different factors. Most of the factors affecting exposure are commonly known by acronym ADME - absorption, distribution, metabolism, and excretion. A fifth factor, solubility, is also very important and is commonly considered to be part of ADME. 

More recently, partially as a result of increased research sophistication and observations made in ADME (Absorption, Distribution, Metabolism, and Excretion) studies, increased attention is being given to evaluating metabolites of APIs. An old example (not being pursued because of the lack of patent protection) is the metabolite... 

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