Absorption-distribution-metabolism-excretion ADME

This book is written for the practicing pharmaceutical scientist involved in absorption-distribution-metabolism-excretion (ADME) measurements who needs to communicate with medicinal chemists persuasively, so that newly synthesized molecules will be more drug-like. ADME is all about a day in the life of a drug molecule (absorption, distribution, metabolism, and excretion). Specifically, this book attempts to describe the state of the art in measurement of ionization constants (p Ka), oil-water partition coefficients (log PI log D), solubility, and permeability (artificial phospholipid membrane barriers). Permeability is covered in considerable detail, based on a newly developed methodology known as parallel artificial membrane permeability assay (PAMPA). 

Absorption, distribution, metabolism, excretion (ADME) studies... 

To focus drug discovery toward effective and orally adsorbable compounds, properties considered are usually related to Absorption, Distribution, Metabolism, Excretion ADME properties). 

In this section, we will review several large-scale applications of data mining methods in the fields of structure-activity and activity-activity relationships (SAR) analyses, and in the areas of absorption, distribution, metabolism, excretion (ADME), and toxicity. 

Pharmacokinetic phase Fate of the dmg in the organism absorption, distribution, metabolism, excretion ( ADME ) Control the bioavailability, i.e. the ratio of the administered dose over the concentration at the site of action, in function of the time... 

Acceptable absorption-distribution-metabolism-excretion (ADME)... 

Absorption, Distribution, Metabolism, Excretion (ADME). Absorption, distribution, metabolism, and excretion are factors critical to toxicity. They are often described by the sciences of toxicokinetics (what the body dose to the chemical) and toxicodynamics (what the chemical does to the body). Although each process is summarized separately below, it must be remembered that each factor influences the others in a continuous process of feedback and response. 

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