Adipocytes glucose uptake

For instance, vanadate inhibited lipolysis and stimulated lipogenesis in adipocytes.Glucose uptake and transport were enhanced by vanadate in... 

Biological actions Adipocyte differentiation fatty acid uptake lipogenesis glucose uptake other effects on nutrient metabolism which lower hepatic glucose production... 

Shikonm stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway. Biochem. Biophys Res Commun. 292 (3) 642-51. 

The promotion by insulin of glucose uptake by muscle and fat cells (adipocytes), of glycogen deposition in liver and muscle, and its stimulation of growth soon emerged as the purified hormone became available for study. Although insulin was crystallized by Abel in 1926, its primary structure established by Sanger in 1953 (see Chapter 10),... 

Insulin action increases glucose uptake by individual fat cells (adipocytes), and this accelerates metabolic activity. 

In persons with diabetes, a major site of Tzd action is adipose tissue, where the drug promotes glucose uptake and utilization and modulates synthesis of lipid hormones or cytokines and other proteins involved in energy regulation. Tzds also regulate adipocyte apoptosis and differentiation. Numerous other effects have been documented in animal studies, but applicability to human tissues has yet to be determined. 

Wang, Q. Bilan, P.J. Tsakiridis, T. Hinek, A. Klip, A. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem. J., 331, 917-928 (1998)... 

Insulin increases glucose uptake into myocytes and adipocytes by triggering movement of the glucose transporter GLUT4 to the plasma membrane. 

Bazuine M, van den Broek PJ, Maassen JA. 2005. Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Biochem Biophys Res Commun 326 511-514. 

Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R, Leighton F. 2005. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 386 471 178. 

Brautigan, D.L., A. Kruszewski, and H. Wang. 2006. Chromium and vanadate combination increases insulin-induced glucose uptake by 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 347 769-773. 

Increased glucose uptake, glucose oxidation, and glucose conversion to fatty acids in adipose tissue, adipocytes and muscle. 

BM 13.0907 (53) lowers blood glucose in ob/ob mice by a mechanism closely resembling that of insulin. In rat adipocytes, BM 13.0907 increases glucose uptake and stimulates the translocation of glucose transporters from intracellular compartments to the plasma membrane [276]. In ob/ob mice, BM 13.0907 normalizes blood glucose at 50 mg/kgp.o. Adipocytes isolated from treated animals display an increase in glucose uptake and an increased ability to translocate glucose transporters [277]. 

---