Adhesives carbomers

Buccoadhesive-controlled release tablets for delivery of nifedipine were prepared by direct compression of carboxymethyl cellulose (CMC) with carbomer (CP) and compared to those prepared with PVP, PVA, HPMC, and acacia by a modified tensiometry method in vitro. It was found that the adhesion force was significantly affected by the mixing ratio of CP CMC in the tablets. CMC is necessary for controlling the release rate, whereas CP is important in providing bioadhesion. The tablets containing 15% CMC and 35% CP were found to have optimum drug release rate and bioadhesion [81]. 

The glass carbomer has similar properties to conventional glass-ionomers in terms of mechanical strength, adhesion and fluoride release. It is somewhat tougher, though. There do... 

Uses Crosslinking agent in adhesives, coatings, inks, textile prods., photoresists, castings, modifiers for polyester, fiberglass, or polymers reactive diluent for radiation-cured inks, lacquers, photosensitive resins Manuf/Distrib. Aldrich CarboMer Fluka Monomer-Polymer Dajac Labs ... 

D nition Contains 5-9% vinyl alcohol, 9-50% vinyl acetate monomers Prq>erties Wh. amoqrhous powd. sol. in phenols, alcohols, aromatic and certain chlorinated soivs. m.w. 24,000-40,000 Uses Phenolic/polyvinylfonnal resins (wire enamels, can coatings) mfg. of paints, adhesives, and films in food-pkg. adhesives in food-con-tact coatings in paper/paperboard in contact with aq./fatty foods Regulatay FDA 21CFR 175.105,175.300,176.170 Manuf./DiM. CarboMer ChissoAm. Fluka Monomer-Polymer Dajac Labs Monsanto... 

Uses Prod, of thermoplastic PU, PU casting elastomers, coatings, adhesives, syn. leather, copolyether esters and amides Manuf./Distrib. Aldrich http //www.sigma-aldrich.com] CarboMer http //www.carbomer.com] Fluka http //www.sigma-aldrich. com Trade Name Synonyms Poly THF t[BASF AG http //WWW. basf. de]... 

Carmellose (carboxymethylcellulose sodium, Na CMC) The adhesion of carmellose to the ocular mucosa is less than carbomer. The solubility of the polymer depends on the degree of substitution. The viscosity decreases during heating and at a pH value Iowct than 5... 

Other rectal dosage forms may be used other than fat-based suppositories. One study describes a liquid suppository that immediately after administration forms a gel with strong adhesion to the rectal mucosa [14]. The gelling at body temperature is caused by a poloxamer. Adhesion to the rectal mucosa is provided by carbomers and cellulose derivates. Compared to a fatty suppository, this delivery system is expected to spread less far into rectum and colon, thereby avoiding the hepatic portal system (see also Sect. 11.3). 

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