Adhesive for Fixing Organic Soft Tissues KL

The cyanaciylate adhesives Eastman (USA), Aron-Alfa (Japan), Kanokonlit (Bulgaria), and MK (CIS) are widely used in medicine, but they have disadvantages decrease of adhesive properties with excess moisture, insufficient film elasticity, comparatively high histo-toxicity, and non-imiversal apphcability as medical adhesives. 

The polyurethane adhesive KL-3 developed by us does not have any topical or systemic toxic effects. Its polymeric film is porous and of high elasticity, and the highly developed surface of the polymer facilitates rapid healing. KL-3 combines the properties of a medical adhesive and of a filling material. Its use is especially indicated when it is necessary to seal tissue defects of considerable size or for closing pathological cavities. 

The biodegradation of KL-3 as a h lrdened composition was studied [419-423]. The degradation of KL-3 in animal tissues is facilitated by two mutually complement lry mechanisms nonenzymatic hydrolysis, and cellular processes. 

Study of the cellular type of biodegradation was possible as a result of investigations on the specific staining of polyurethane fragments in archived preserved preparations with the use of Sudan III-IV stain [425, 426]. Binding of polymer fragments to this stain produces a red-orange color, which makes it possible to identify not only free polyurethane particles but also intracellular p u ticles. 

The products of biodegradation of KL-3 pol5mieric films are excreted by the organism via the urinary system and the gastrointestinal tract and do not accumulate in tissues and organs [428]. 

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