Adenovirus subgroups

The primary cellular attachment receptor for adenovirus has not yet been identified, but the vitronectin-binding integrins Oy/Sj and Oy/ s have been shown to be coreceptors for viral internalization [113] and interact with the penton base of the capsid. It is thought that the initial interaction with the cell surface is mediated by the protruding fiber proteins. The various subgroups presumably bind to different receptors because they do not compete with one another for cellular binding. Subsequent interactions between the Oy coreceptors and the penton base... 

Adenoviruses are nonenveloped, double-stranded DNA viruses. There are more than 50 different serotypes of human adenoviruses that have been divided among 6 different subgroups (A-F) based on serologic and... 

Wigand, R., Gelderblom, H., and Wadell, G. 1980. New human adenovirus (candidate adenovirus 36), a novel member of subgroup D. Arch. Virol. 64, 225-233. 

Fig. 2. (A) Structure of the adenovirus ElA and ElB early genes. The region 0-11 units (1 unit = 366 bp) of the subgroup C adenovirus genome is represented by the solid horizontal line in the center of the figure. The mRNA species complementary to each region are depicted by horizontal arrows above the genome drawn in the direction of transcription, in which the solid arrows and gaps represent sites of po-lyadenylation and sequences removed during splicing, respectively. The structures...

Marusyk, R. G., Morgan, A. R., and Wadell, G., 1975, Association of endonuclease activity with serotypes belong to the three subgroups of human adenoviruses, J. Virol. 16 456. 

Perricaudet, M., Akusjarvi, G., Virtanen, A., and Pettersson, U., 1979, Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses, Nature London) 281 694. 

Tomko RP, Xu R, Philipson L. HCAR and MCAR the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci USA 1997 94 3352-3356. 

Roelvink PW, Lizonova A, Lee JG, Li Y, Bergelson JM, Finberg RW, Brough DE, Kovesdi I, Wickham TJ. The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes fiom subgroups A, C, D, E, and F. J Virol 1998 72 7909-7915. 

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