Adam site

Adam site Brit design for diphenylamino-chloroarsine (CWA)... 

Z.H. Zhou, M.W.W. Adams, Site-directed mutations of the 4Fe-ferredoxin from the hyperthermophilic archaeon Pyrococcus furiosus role of the cluster-coordinating aspartate in physiological electron transfer reactions. Biochemistry 1997, 36(36), 10892-10900. 

No details, but I believe that this is the same work as described by Adam McLean on his web site. This extract is taken from The Theosophical Transactions of the Philadelphian Society. This short lived magazine (four issues appeared during 1697) was edited by Francis Lee, the son-in-law of the English mystic Jane Lead who was the major figure behind the Philadelphian Society. Most of the articles in this magazine were published... 

Flamel, Nicholas. Testament of Nicholas Flamel. London Printed by J. E. Hodson, No. 15, Cross-Street, Hatton-Garden and sold only by the editor..., 1806. vp "This text is probably a late invention but it is nevertheless interesting for that. I cannot locate a manuscript of the Testament, though it was mentioned in Borel s bibliography of alchemy. It was probably written in France in the late 18th century, during the revival of interest in Flamel" [from Adam McLean s web site]. Editor I.A.T. 1. Some account of Nicholas Flamel and his works 26p 2. Testament... 20p. 

These texts are an attempt to add to the number of alchemical related writings on the internet. I plan to avoid adding anything that is already online at Adam Mclean s incredible website (or any other site for that matter). Many of the first texts going up will be from the material released by R.A.M.S."... 

Web site with an extensive alchemy archive. Costs 20 to obtain a password to enter the site. Email joshua.gulick hotpop.co for details. It seems that some of the material is taken from Adam McLean s web site... 

McLean, Adam. The Alchemy web site, f http //www.levltv.com/alchemvl. 

Greig, R.A., D.R. Wenzloff, A. Adams, B. Nelson, and C. Shelpuk. 1977. Trace metals in organisms from ocean disposal sites of the middle eastern United States. Arch. Environ. Contam. Toxicol. 6 395-409. 

Figure 5.9 Ligands (A) N,S-mpy, (B) N4-mpy, (C) N2S2-mpy, and (D) N2S2-inim designed to mimic azurin and plastocyanin active sites. (Adapted with permission of The Royal Society of Chemistry from Malachowski, M. R. Adams, M. Elia, N. Rheingold, A. L. Kelly, R. S. J. Chem. Soc., Dalton Trans., 1999, 2177-2182.

Smith, G., Adams, T. V., and Jurka, V., 1998, Closing a DNAPL Site through Source Removal and Natural Attenuation In Physical, Chemical, and Thermal Technologies — Remediation of Chlorinated and Recalcitrant Compounds (edited by G. B. Wickramanayake and R. E. Hinchee), Battelle Press, Columbus, OH, pp. 97-102. 

Beyond these, MEDLINEplus contains a very patient-friendly encyclopedia covering every aspect of medicine (licensed from A.D.A.M., Inc.). The ADAM Medical Encyclopedia can be accessed at http //www.nlm.nih.gov/medlineplus/encyclopedia.html. ADAM is also available on commerdal Web sites such as drkoop.com (httpv/www.drkoop.conV) and Web MD (http my.webmd.com/adam/asset/adam disease articles/a to z/a). 

Wong L., Lieser S., Chie-Leon B., Miyashita O., Aubol B., Shaffer J., Onuchic J.N., Jennings P., Woods V.L. Jr, Adams J.A. Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J. Mol. Biol. 2004, 341, 93-106. 

Another zinc-utilizing enzyme is carbonate/dehydratase C (Kannan et al., 1972). Here, the zinc is firmly bound by three histidyl side chains and a water molecule or a hydroxyl ion (Fig. 27). The coordination is that of a distorted tetrahedron. Metals such as Cu(II), Co(Il), and Mn(ll) bind at the same site as zinc. Hg(II) also binds near, but not precisely at, this site (Kannan et al., 1972). Horse liver alcohol dehydrogenase (Schneider et al., 1983) contains two zinc sites, one catalytic and one noncatalytic. X-Ray studies showed that the catalytic Zn(II), bound tetrahedrally to two cysteines, one histidine, and water (or hydroxyl), can be replaced by Co(II) and that the tetrahedral geometry is maintained. This is also true with Ni(Il). Insulin also binds zinc (Adams etai, 1969 Bordas etal., 1983) and forms rhombohedral 2Zn insulin crystals. The coordination of the zinc consists of three symmetry-related histidines (from BIO) and three symmetry-related water molecules. These give an octahedral complex... 

Pollino JM, Nair KP, Stubbs LP, Adams J, Week M. Crosslinked and functionalized universal polymer backbones via simple, rapid, and orthogonal multi-site self-assembly. Tetrahedron 2004 60 7205-7215. 

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