Acyclic Saturated Alcohols

Oxidation of Saturated Alcohols. Cyclic and acyclic saturated alcohols react with Mn02 to give the saturated aldehydes or ketones in good yields (eqs 29-32). ... 

ACYCLIC SATURATED ALCOHOLS 3.2.1. Methyl alcohol CH3OH General information... 

Cyclic enol ethers are reductively cleaved to produce a,to-diols using a stoichiometric amount of benzyltriethylammonium borohydride and chlorotrimethylsilane [30] acyclic enol ethers give saturated alcohols. 

TABLES OF OPTICALLY ACTIVE ALCOHOLS AND PHENOLS 407 TABLE I—Continued Acyclic Saturated Monoalcohols... 

The acyclic terpene alcohols geraniol, linalool, and citronellol are the most important terpene alcohols used as fragrance and flavor substances. Geraniol and linalool are, in addition to nerol and lavandulol, primary products in terpene biosynthesis. The fully saturated alcohols tetrahydrogeraniol and tetrahydrolinalool are also... 

Whereas cyclic allyhc alcohols of normal size can only yield (Z)acyclic allylic alcohols preferentially give ( )-isomers. Indeed, the Meerwein-Eschenmoser-Claisen rearrangement is an excellent method for the stereoselective formation of di- and trisubstituted (E)-double bonds in acyclic systems. The high diastereoselectivities observed (dr >95 5) can be explained by invoking a chair shaped transition state 35a or 36a (Scheme 7.15). This minimizes... 

In this section, a structure-activity relationship is developed that applies to reactions of Cl-atoms with acyclic, saturated, monofunctional alcohols and ethers. The relationship... 

Optically Active Alcahnls and Esters In addition to the hydrolysis nl esters formed by simple alcohols described above, lipases and esterases also catalyze the hydrolysis ot a wide range of esters based on more complex and synthetically useful cyclic and acyclic alcohols. Although the hydrolysis of acetates often gives the desirable resolution, to achieve maximum selectivity and reaction efficiency, comparison of various esters is recommended. Both saturated and unsamraicd derivatives are easily accepted by lipases and esterases. 

Fatty Acids and Fatty Alcohols Fatty acids are traditionally meant as aliphatic unbranched monocarboxylic acids, either saturated or unsaturated, but with a chain length of 4 to 28 carbon atoms. Sometimes even shorter acyclic aliphatic carboxylic acids like acetic acid are named fatty acids, although they are not found in oils and fats [19]. 

The consumption of six moles of periodic acid by streptamine without the liberation of formaldehyde showed the absence of primary alcohol groups. This observation along with the fact that analytical data on several salts of streptidine showed it to have two hydrogen atoms less than the number required for a saturated acyclic compound (bromine water, infrared and ultraviolet absorption spectra gave no indication of... 

A transition metal catalyzed synthesis of ethers by carbene insertion into the O—bond has been reported. Not only saturated but also unsaturated alcohols can be utilized in this catalytic process. ° Intermolecular and intramolecular oxirane ring opening reactions by alkoxides and phenoxides also provide efficient and stereospecific preparations of acyclic and cyclic ethers. The procedures have been surveyed in detail. ... 

There are four constitutional isomers of the saturated acyclic four-carbon alcohols with one Acyclic compounds contain no rings. —OH per molecule. Write the structural formula of each, and identify each as primary, secondary, or tertiary. Name each isomer. 

When the dry ozonation technique is employed (dry silica gel with a preadsorbed organic substrate is saturated with ozone at -78°C then warmed up to room temperature), ozone exhibits an enhanced reactivity, presumably due to the slightly acidic nature of silica gel. Regioselectivities and stereoselectivities under these conditions are very similar to those in superacidic liquid-phase ozonation. Straight-chain alkanes are oxidized at the secondary carbon to yield a mixture of alcohols and ketones, Branched acyclic alkanes give tertiary alcohols and yield ketones via C-C bond cleavage, Insertion of ozone into the C-H and C-C a bonds was evoked to account for the observations (Scheme 6.27). 

Amines caimot undergo the substitution and elimination reactions that alkyl halides undergo, because the leaving groups of amines are too basic. Protonated amines also cannot undergo the reactions that protonated alcohols and protonated ethers undergo. Amines are easily oxidized. Saturated heterocycles containing five or more atoms have physical and chemical properties typical of acyclic compounds that contain the same heteroatom. 

N, v= valence of X). This class of Saturated Acyclic Monofunctional (SAM) derivatives includes amines, alcohols, thiols, ethers and thioethers. The emphasis was on keeping the program units as general as possible but tuning their heuristics to ensure drastic pruning, yet never allowing the correct structure to be absent from the final output of candidates. 

Like saturated acyclic alcohols, aromatic alcohols, which are widely used in perfumery,... 

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