Acute polyneuritis

Acute idiopathic polyneuritis characterized by muscular weakness and paraesthesia. 

Tuberculous patients lacking in liver N-acetyl transferase who are treated with isoniazid are likely to develop polyneuritis (39). An enzyme abnormality is also responsible for the precipitation of acute intermittent porphyria by the barbiturate drugs (40). Likewise, the rare hereditary resistance to coumarin anticoagulant drugs is thought to be due to an enzyme deficiency (41). 

Eike SEE, PAN has a wide range of clinical manifestations. These include fever, weight loss, severe abdominal and musculoskeletal pain, tachycardia, acute glomerulonephritis, polyneuritis, myocardial inferction, and such pulmonary manifestations as bronchial asthma. The frequency of this disease is approximately 8 per 1,000 population, but the clinical diagnosis rate is considerably lower than postmortem studies suggest. In the United States incidence is reported to range from 3 to 4.5 cases per 100,000 population per year. Renal involvement is one of the most common and devastating aspects of... 

Fisher M (1956) An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia ataxia and areflexia). N Engl J Med 255 57-65. 

A 39-year-old woman developed a severe sensori motor polyneuritis after taking ethanol and disulfiram in high doses (8). The disorder was similar to other cases of disulfiram neuropathy, but was acute and more severe. 

Acute infectious polyneuritis Landry s ascending paralysis Strohl syndrome... 

Caution Most forms of arsenic are toxic. Acute symptoms following ingestion relate to irritation of the G.I. tract nausea, vomiting, diarrhea which can progress to shock and death. Chronic poisoning can result in exfoliation and pigmentation of skin, herpes, polyneuritis, altered hematopoiesis, degeneration ol liver and kidneys Vaiiee et al. Arch. 

Caution Symptoms of acute toxicity include nausea, vomiting, diarrhea, tingling, pain in extremities, weakness, coma, convulsions, death. Chronic weakness and pain in extremities (polyneuritis), loss of hair E. Browning, Toxicity of Industrial Metals (Appleton-Century-Crofts, New York, 2nd ed., 1969) pp 317-322. 

Fisher, M. Unusual variant of acute idiopathic polyneuritis s3nidrome of ophthalmoplegia, ataxia and areflexia. New. Engl. J. Med. 255, 57 (1956). 

Peripheral neuropathy, due to involvement of the vasa vasorum, is noted in 30% to 43% of patients during the course of the disease (3,5,79-81,91). Most common manifestations include mononeuritis multiplex or polyneuritis (3,5,79). Peripheral neuropathy is more common in males, older age, greater extent of disease, and higher titers of ANCA (79). In some patients, biopsy of the sural nerve or other affected nerves may substantiate the diagnosis. Both peripheral and CNS manifestations may be associated with irreversible damage, persisting even after the acute inflammation is adequately controlled. 

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