Acute inflammatory demyelinating

Acute inflammatory demyelinating polyradiculopathy Early pre-AIDS Acute Motor to sensory signs NCS show demyelinating features Immune dysfunction complement/macrophage-mediated demyelinating neuropathy... 

Acute inflammatoiy demyelinating polyneuropathy is a common cause of reversible paralysis. Acute inflammatory demyelinating polyneuropathy (AIDP), the classic form of the Guillain-Barre syndrome, often begins a week or two after recovery from cytomegalovirus, Epstein-Barr virus or Mycoplasma infection. Patients present with rapidly advancing symmetrical weakness, loss of deep tendon reflexes, often with distal numbness, and limb or back pain. Cerebrospinal fluid (CSF) protein concentration is elevated, but in most cases there is little or no increase in number of inflammatory cells in the CSF. This albumino-cytologic dissociation contrasts with the elevation of both... 

Magira, E. E., Papaioakim, M., Nachamkin, I. et al. Differential distribution of HLA-DQP/DRP epitopes in the two forms of Guillain-Barre syndrome, acute motor axonal neuropathy and acute inflammatory demyelinating... 

Figure 20.1. Hypothetical scheme of the immune response in acute inflammatory demyelinating polyradiculoneuropathy (AIDP) Inflammatory cells migrate from the systemic immune compartment through the damaged blood-nerve barrier into the endoneurium. Inflammatory infiltrates, which contain T-lymphocytes and macrophages cause marked segmental demyelination and secondary axonal degeneration (B B-cell T T-cell M4> Macrophage).

Hafer-Macko C, Sheikh KA, Li CY, Ho TW, Comblath DR, McKhann GM, Asbury AK, Griffin JW (1996b) Immune attack on the Schwaim cell surface in acute inflammatory demyelinating polyneuropathy. Ann Neurol 39 625-635. 

Hu W, Mathey E, Hartung HP, Kieseier BC (2003) Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve. Neurology. 61 1774—1779. 

AID AIDP AIDS AIF AIRE AIS AES AMAN AMN AMPA AMSAN activation-induced (cytidine) deaminase acute inflammatory demyelinating polyradiculoneuropathy acquired immunodeficiency syndrome apoptosis inducing factor autoimmune regulator anterior chamber associated immune deviation (ACAID)-inducing signal amyotrophic lateral sclerosis acute motor axonal neuropathy adrenomyeloneuropathy a-amino-3 -hydroxy-5-methylisoxazole- 4-propionic acid acute motor-sensory axonal neuropathy... 

Wanschitz J, Hainfellner JA, Simonitsch I, et al. Non-HTLV-I associated pleomorphic T-cell lymphoma of the brain mimicking post-vaccinal acute inflammatory demyelination. Neuropathol Appl Neurobiol. 1997 23 43-49. 

Nervous system Demyelinating disorders provoked by mAbs are said to affect 0.02-0.2% of treated patients. Three patients with chronic lymphocytic anaemia developed acute inflammatory demyelinating neuropathy while being treated with alemtuzumab [90 ]. All three showed a good clinical response to treatment with intravenous immunoglobulin. 

Lahbabi M, Ghissassi M, Belahcen F, Ibrahimi SA, Aqodad N. Acute inflammatory demyelinating polyneuropathy after treatment with pegylated interferon alfa-2a in a patient with chronic hepatitis C virus infection a case report. J Med Case Rep 2012 6 278. http //dx.doi. org/10.1186/1752-1947-6-278. 

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