Acute Effects on Metabolic Blood Parameters in Conscious Dogs

Acute Effects on Metabolic Blood Parameters in Conscious Dogs 

Since most safety studies for safety pharmacological evaluation of candidate compounds are performed in rodents a second non-rodent species should be included to exclude any species differences in the safety pharmacological findings. Dogs are a preferred second animal species in metabolism pharmacology, because their night/day activity, their food intake behaviour and therefore their intermediary metabolism is obviously different to that of rodents and resembles more that of humans. 

Averages of the metabolic blood parameters (e.g. glucose, lactate) are plotted versus time for each dosage. Besides the original values, percentage data related to the value before the experiment are calculated. Similarly, plasma insulin levels are plotted versus time and compared with control values. Statistical evaluation is performed using appropriate methods. 

Bergmeyer HU (1974) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim 

Bander A, Pfaff W, Schmidt FH, Stork H, Schroder HG (1969) Zur Pharmakologie von HB 419, einem neuen, stark wirk-samen oralen Antidiabeticum. Arzneim Forsch/Drug Res 19 1363-1372 

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