Pharmacology and Metabolism

Hartmann, J. T., Haap, M., Kopp, H. G. 8c Lipp, H. P. Tyrosine kinase inhibitors - a review on pharmacology, metabolism and side effects. Curr. Drug Metab. 10, 470-481 (2009). 

Migdalof BH, Antonaccio MJ, McKinstry DN, et al. Captopril pharmacology, metabolism and disposition. Drug Metab Rev 1984 15(4) 841-869. 

Rowinsky EK, Wright M, Monsarrat B, Lesser GJ, Donehower RC. Taxol pharmacology, metabolism and clinical implications. Cancer Surv 1993 17 283-304. 

Burstein, S., in "Marijuana, Chemistry, Pharmacology, Metabolism and Clinical Effects", Ed. 

In recent years there has been a great increase in interest in the pharmacology, metabolism and biodisposition of the cannabinoids for recent reviews cf. Mechou-lam (1), Paton and Crown (2), Wall (3) and Wall et al. 

Drapeau G, Brochu S, Godin D, Levesque L, Rioux F, Mai ceau F (1993) Syntlretic C5a receptor agonists Pharmacology, metabolism and in vivo cai diovasculai and hematologic effects. Biochem Pharmacol 45 1289—99. 

Mechtxilam, R. (1973). Cannabinoid chemistry. In R. Mechoulam (Ed.), Marijuana Chemistry, pharmacology, metabolism, and clinical effects pp. 2-99). 

Chemistry, Pharmacology, Metabolism and Clinical Effects, R. Mechoulam (ed.), Academic Press, New York, 1973. Many of these possess the activity of the natural compounds, frequently at lower dosages and of longer duration, such as in the monkey test, 24 hours instead of 4 hours with the 1", 2"-(dimethylheptyl) homologue of (3R,4R)-(-)Al-THC (III). The corresponding A6 -THC compound (IV) acts at 0.5 mg/kg for 30 hours. 

Except for some work on the topical antibiotic properties of cannabinoid acids [49], medicinal chemical work in this field essentially stopped until 1964, when the major active constituent, A -THC, was isolated in a pure form and its structure was elucidated [50]. Since then, thousands of papers on the chemistry, pharmacology, metabolism and clinical effects of A -THC (1) have been published. On the basis of the knowledge accumulated, a considerable... 

W.D.M. Paton and R.G. Pertwee in Marijuana, Chemistry, Pharmacology, Metabolism and Clinical Effects, ed., R. Mechoulam (Academic Press, New York, 1973) pp. 191-333. 

MECHOULAM, R. (Ed.) 1973. Marijuana Chemistry Pharmacology Metabolism and Clinical cts. Academic Press, New York. 

Paton, W.D.M, etal 1973. Clinical aspects of Cannabis action In Mechoulam, R. (Ed.) Marijuana Chemistry, Pharmacology, Metabolism and ClinicalEffcts. Aca-... 

All reports should generally be checked independently by (ideally) two suitably qualified staff members. The laboratory should implement a policy regarding the provision of opinions and interpretation of data. The basis on which an opinion has been stated must be documented. An opinion or interpretation may include, but not be limited to, recommendations on how to use results, or information related to the pharmacology, metabolism, and pharmacokinetics of a substance. This is particularly important for classes of compounds for which the client/authority may not be aware of the latest developments or recent knowledge in the field, as is often the case, for instance, for natural hormones such as boldenone and nandrolone in breeding animals, compounds newly discovered to be naturally occurring such as thiouracil, and marker residues that may be unreliable such as semicarbazide as a marker for nitrofurazone abuse. °... 

Additionally, LC-MS is the method of choice for the separation and detection of chiral impurities in pharmaceuticals. The analysis of chiral impurities in pharmaceuticals is of importance because the D-isomer of a dmg can have a different pharmacological, metabolic, and toxicological activity from the L-isomer. Chiral impurities of amino acids, present in peptide drugs, have been separated and determined by LC-MS. The selectivity of MS detection eliminated interference from other peaks that appeared when a UV detector was used for detection. 

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