Acute Effects on Mammals and Humans

Administration of gallium compounds produced pulmonary and kidney injury, and altered various steps of the heme biosynthesis pathway, in part due to the induction of heme oxygenase (Fowler et al. 1993). 

Gallium arsenide has been shown to be an immunosuppressant. When administered intratracheally to mice at concentrations between 50 and 200 mg kg GaAs suppressed the in-vivo antibody-forming cell (AFC) response to sheep erythrocytes (SRBC), and interfered with antigen processing that is essential for CD4+ T-cell stimulation by splenic macrophages (Sikor-ski etal. 1991, Lewis TA etal. 1996). The arsenic moiety appears to be responsible 

---