Antioxidants activator protein

Kim, Y., Chongviriyaphan, N., Liu, C., Russell, R.M., and Wang, X.D. 2006. Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. 

Mishra, N.P., Mishra, R.K. and Singhal, C.S. (1993). Changes in the activities of antioxidant enzymes during exposure of intact wheat leaves to strong visible light at different temperatures in the presence of protein synthesis inhibitors. Plant Physiology 102 903-910. 

Kyaw, M., Yoshizumi, M., Tsuchiya, K., Izawa, Y., Kanematsu, Y., and Tamaki, T., Atheropro-tective effects of antioxidants through inhibition of mitogen-activated protein kinases, Aeta Pharmacol Sin., 25, 911, 2004. 

Bazzoli DL, Hill S, DiSilvestro RA. Soy protein antioxidant actions in active, young adult women. Nutr. Res. 22, 807-815, 2002. 

Katsuoka F, Motohashi H, Ishii T, Aburatani H, Engel JD, Yamamoto M. 2005. Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Mol Cell Biol 25 8044-8051. 

Other putative effects of estrogens include preservation of autoregulatory function, an antioxidant effect, reduction of A(i production and neurotoxicity, reduced excitotoxicity, increased expression of antiapoptotic factor bcl-2, and activation of mitogen-activated protein kinase pathways. Also, there is overwhelming data indicating that estrogens enhance survival of neurons both in vitro and in vivo (Green and Simpkins, 2000). 

Medical observations and research suggest that oxidative stress can be related to the occurrence of memory loss, implying that this adverse effect can be restricted by application of bilirubin as an antioxidant. It has been found that bilirubin possesses antioxidative activity and prevents pathological changes which appear in multiple sclerosis patients, but does not reveal any immunosuppressive effects (Liu et al. 2003). Lack of oxidative and antioxidative balance in pneumonia can activate such transcription factors as NF-kB and activating protein-1 (AP-1), which are sensitive to the redox potential (Rahman 2000). 

Saab-Rincon G, Valderrama B (2009) Protein engineering of redox-active enzymes. Antioxid Redox Signal 11 167-192... 

Sethi, J.M., Otterbein, L.E., Choi, A.M.K. (2002). Differential modulation by exogenous carbon monoxide of TNF-a stimulated mitogen-activated protein kinase in rat pulmonary artery endothelial cells. Antioxid. Redox Signal. 4 241-58. 

Yu R, Chen C, Mo Y-Y, Owuor ED, Tan T-H, et al. 2000. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J. Biol. Chem. 275 39907-13... 

Kang KW, Ryu JH, Kim SG. 2000. The essential role of phosphatidylinositol 3-kinase and the p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells. Mol. Pharmacol. 58 1017-25... 

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