Acryl chloride

A general route to [l,2,4]triazolo[3,2-A][l,3]thiazines was discovered by Britsun etal. <2001ZOR1102, 2004KGS1256, 2004ZOR260>. In these publications, reaction of triazole thiones 332 with various substituted acrylic chlorides was reported to yield a series of ring-closed products 333 with the substituent of the reagent in the six-membered ring at the position adjacent to the sulfur atom. 

Allyl acetate CH2= CHCH2OCCH3 Allyl alcohol CH2 = CHCH2OH Acryl chloride CH2 = CHCH2C1... 

A reactor containing the step 1 product (106.47 g), N,N -dimethy kini line (109 g), 2,6-di-t-butyI-4-mcthyl-phenol (0.9 g), and 1000 ml of dioxane at ambient temperature was treated with the dropwise addition of acrylic chloride (80 g) and then stirred at... 

Acrylamide(Propenamid or Acryl s aureamid in GerJjCHj CH. CO. NHa ndls, mp 84 5°, dec < 125°. Can be prepd by saturating a cooled ben2 soln of acrylic chloride with dry NH3(Refs 2 3)... 

Tile monomer was prepared by dissolving 2,2-dinitropropanol and acrylic chloride in carbon tetrachloride and heating for 12 hours at 55 C. The dried product was mixed with powdered silver and vacuum distilled. It can be used as a binder in propellants burning readily at a pressure of ca. 70 kg/cm. It can be polymerized in toluene in the presettee of azobisisobutyroniiriic as a free radical catalyst, under dry nitrogen at SO C for 45 min. The conversion of. 25% was obtained to yield the polymer ... 

The classical Hofmann elimination reaction (which dates back to 1851) has been adapted to the solid phase in combination with the Michael addition. The REM resin, called this way because the resin tinker is REgenerated after product cleavage and functionalized by means of a Michael addition, has been developed to prepare arrays of tertiary amines. The procedure involves acylation of hydroxy-methylpolystyrene with acrylic chloride to furnish the acrylate on resin. Then, a secondary amine, whose substituents offer two potential sites of diversity, is bound by Michael addition. Quaternization of the amine with an alkyl halide (or reductive animation) introduces another site of diversity and activates the tinker to release the amine by a Hofmann elimination with DIEA (Figure 15.14) [127-129]. Additionally, the use of a second basic resin has been described as a source reagent to promote the elimination [130, 131]. 

Gribel, T. Kuhcke, W.-M. Hansemzaden A. Characterization of water-soluble polyelectrolites as examinated by poly(acrylamide-co-trimethylammonium-acrylate chloride) and establishment of structure-property relationships. Colloid Polymer Sci., 1991,269(1), 113-120. 

---