Aconitine-induced arrhythmias

Anti-arrhythmic activity Ethanol (95%), glycerin, and glycerin/ethanol extracts of the leaf, administered intragastrically to rats at a dose of 25 mg/kg, were active vs aconitine-induced arrhythmia " . Ethanol (95%) and glycerin extracts of the seed oil, administered intragastrically to rats at a dose of 25 mg/kg, were active " . Anti-atherosclerotic activity. Extracts of leaves of three isolates (Greek olive leaves [GO], African wild olive leaves [AO], and Cape Town olive leaves [CT]), administered to Dahl salt-sensitive, insulin-resistant rats at a dose of 60 mg/kg for 6 weeks, were active ". ... 

Treatment of intoxication is supportive. No specific antidote is presently known. M-cholinoblockers (atropine) are indicated to treat bradycardia. Amiodarone and flecainide can be recommended for the treatment of aconitine-induced arrhythmia. Ventricular arrhythmias provoked by aconitine are often refractory to direct current cardioversion and antiarrhythmic drugs. In refractory cases of ventricular arrhythmias and cardiogenic shock, the cardiopulmonary bypass is recommended. 

Amran MS, Hashmoto K, Homma N (2004) Effects of sodium-calcium exchange inhibitors, KB-R7943 and SEA0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies. J Pharmacol Exp Ther 310(l) 83-89... 

Aconitine, 1170, 1188, 1506, 1508 Aconitine-induced arrhythmia, 1511 Aconitine type, 933 Aconitorientaline, 935 Aconitum, 1188, 1505 A. carmichaelii, 1505 A. columbianum, 1505 A.ferox, 1505 A. karakolicum, 1512 A. lycoctonum, 1505 A. napellus, 1505 Acorus calamus, 4095 Acquired resistance, 3976 Acridone, 717 Acronychia, 723... 

It is noteworthy that calcium inhibitory compounds with the ability to inhibit %a+ possess the most potent antiarrhythmic activity against both experimental and clinical arrhythmias (126). For example, nifedipine exerts minimal, if any, antiarrhythmic effect against ischemic induced arrhythmias in intact animals (6, 87, 131). Diltiazem and perhexiline, on the other hand, demonstrate variable antiarrhythmic effects dependent upon their dose and the mechanism responsible for arrhythmia production (ischemia, hypoxia, digitalis, aconitine) (102, 126, 151, 152). Only verapamil, which has been investigated in the largest number of experimental and clinical trials, has demonstrated consistent antiarrhythmic activity against cardiac arrhythmias regardless of cause (155) ... 

French G (1958). Aconitine-induced cardiac arrhythmia. Br. Heart J. 20 140-142. 

The most toxic alkaloids of aconite, such as aconitine, mesaconitine, hypaconitine, etc., are known to possess arrhythmogenic effect. Aconitine itself has long been used to induce arrhythmia in experimental models [38, 39]. Aconitine and its structural analogues induce ventricular ectopics, ventricular tachycardia, torsades de pointes, and ventricular fibrillation in a dose-dependent manner. Aconitine has a positive inotropic effect on the heart. It has hypotensive and bradycardic actions [40]. Another group of diterpenoid alkaloids possessing C18 and C19 skeleton, such as lappaconitine, A -deacetyllappac(Miitine, heteratisine, and 6-benzoylheteratisine, are... 

Lappaconitine (2) this compound is 40 times less toxic than aconitine (1). In anesthetized rabbits it induced cardiac arrhythmias, preceded by bradycardia and fall in blood pressure [11]. 

Highly toxic used to induce heart arrhythmia in experimental animals Aconitine. Alkaloid of Aconitum napellus... 

Intravenous administration of (+)-isocorydine hydrochloride to anesthetized rats at a dosage of 5-20 mg/kg significantly counteracted the arrhythmias induced by intravenously administered barium chloride (3 mg/kg) or aconitine (20 mg/kg), and decreased the incidence of ventricular fibrillation, as well as the mortality rate [332]. 

R-8I8 (17) prevented chloroform-induced ventricular fibrillation in mice as well as arrhythmias caused by hydrocarbon-epinephrine, ouabain, aconitine and coronary occlusion in dogs.5° The activity of numerous analogs in the mouse chloroform test has been described.57... 

The substances were studied in vivo in rats at a dose equivalent to 30 mg/kg of the pharmacon per os, in an experimental model of heart-rhythm disturbance induced by the intravenous administration of aconitine [28], The relative time (t) (compared with the control) until the onset of arrhythmia after aconitine administration served as an index of the antiarrhythmic activity. 

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