Acneiform eruption

Impaired wound healing, thin fragile skin, petechiae, ecchymoses, erythema, increased sweating, suppression of skin test reactions, subcutaneous fat atrophy purpura, striae, hyperpig mentation, hirsutism, acneiform eruptions, urticaria, angioneurotic edema... 

Acneiform eruption after deep chemical peel is a common phenomenon appearing immediately after reepithelialization. Its etiology is multifactorial and is related to either exacerbation of previously existing acne or is due to over-greasing of newly formed skin. Short-term systemic antibiotics together with discontinuation of any oily preparations will usually provide satisfactory solution. 

Bosch Garcia, R.J., Gallardo, M.A. and Herrera Ceballos, E. (2001) Acneiform eruption caused by amineptine. A case report and review of the literature. Journal of the European Academy of Dermatology and Venereology, 15, 337-339. 

Adverse reactions may include acneiform eruptions allergic dermatitis arthropathy multiple cases of cholestatic and fulminant hepatitis drowsiness fatigue headache hepatotoxicity resembling viral or alcoholic hepatitis impotence metallic or garlic-like aftertaste peripheral neuropathy polyneuritis optic or retrobulbar neuritis restlessness occasional skin eruptions. 

Adverse events are rare and mostly allergic reactions such as urticaria and acneiform eruptions that probably can be attributed to impurities and preservatives in the preparations. 

Dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral... 

Early in the course of lithium therapy, exacerbations of psoriasis and acneiform eruptions as well as other skin reactions may occur. Possible mechanisms have included lithium s ability to decrease cAMP as well as to increase the number and activity of polymorphonuclear leukocytes. Those with a predisposition to skin disorders are most at risk for this complication, with women more likely than men to experience a dermatological reaction to lithium. These problems may clear spontaneously or may require lithium dose reduction, appropriate dermatological intervention, or lithium discontinuation ( 77). 

Transient acneiform eruptions have been noted early in lithium treatment. Some of them subside with temporary discontinuance of treatment and do not recur with its resumption. Folliculitis is less dramatic and probably occurs more frequently. Leukocytosis is always present during lithium treatment, probably reflecting a direct effect on leukopoiesis rather than mobilization from the marginal pool. This adverse effect has now become a therapeutic effect in patients with low leukocyte counts. 

Discharges from the acneiform eruptions of two patients analyzed at 32 and 45 ppm PCBs. An 18 year old male showed ca. 75 and 13 ppm in subcutaneous fat samples taken from his face and abdomen, respectively. GLC patterns similar to those in contaminated rice oils were found in the human samples examined, including those from fetal and placental tissues. Tissues from a stillborn infant (October 1968) were preserved for later analysis. These had PCB concentrations in liver, skin and fat of 1.8, 1.2 and 0.1 ppm, respectively. The pregnant mother had been diagnosed as a severe case of Yusho. First trimester PCB concentrations reported for 19 embryos were low (<2ppb). Second and third trimester were successively higher (Table 9) ... 

Acne-prone skin is often classified under the sensitive skin category by cosmetic consumers. However, as many dermatologists consider it to be a separate clinical entity, acne-prone skin and acneiform eruptions will not be discussed here. 

Severe allergic skin reactions, alopecia, acne, and purpura can occur in patients taking ethionamide (1,12). Other adverse effects include acneiform eruptions, photodermatitis, and hair loss (13). 

Morbilliform, maculopapular, or urticarial rashes have been observed in up to 2% of patients (9). In one study, acneiform eruptions developed in only 11 cases (1.4%), including 0.5% of patients taking isoniazid, 1.5% of patients taking rifampicin, and 0.6% of patients taking ethambutol (36). 

Sharma RP, Kathari AK, Sharma NK. Acneiform eruptions and anti-tubercular drugs. Indian J Dermatol Venereol Leprol 1995 61 26. 

All the cobalamins have the same pattern of adverse reactions. The adverse effects of high doses of cobalamins include urticaria, eczematous and exanthematous skin lesions, and anaphylactic reactions (SEDA-4, 265), but it is not clear whether the reactions are caused by the drug itself, a preservative, or possibly by contaminants. High oral or parenteral doses of vitamin Be and especially hydroxocobalamin are also on rare occasions suspected to induce acne which is, however, always benign (SEDA-5, 347) (1). Several cases of vitamin Bi2-induced folliculitis and acneiform eruptions have been described, in one case in connection with a patient receiving total parenteral nutrition (2). 

Corticosteroids 2-i times/day Local tissue atrophy, degeneration, and striae epidermal thinning acneiform eruptions baderial or fungal skin infections glucocorticoid systemic effects... 

TOXICITY AND MONITORING Chronic use of potent topical glucocorticoids (e.g., diflo-rasone diacetate 0.05%, betamethasone dipropionate 0.05%) can cause skin atrophy, striae, telang-iectasias, purpura, and acneiform eruptions. Because perioral dermatitis and rosacea can develop after the use of fluorinated compounds on the face, they should not be used in this site. 

Exceptional adverse reactions of undefined etiology following tetracycline administration do exist. Bean (1971) reported acneiform eruptions occurring in a... 

Int Arch Allergy Appl Immunol 51 390-394 Bean SF (1971) Acneiform eruption from tetracycline. Br J Dermatol 85 585-586 Beaty HN, Petersdorf RG (1966) Iatrogenic factors in infectious disease. Ann Intern Med 65 641-656... 

Acneiform eruptions These usually develop a few days after peeling and may persist for 1 month (Fig. 23.6)... 

Acne-prone skin, as well as use of occlusive products during the reepithelialization phase or immediately after, may result in an acneiform eruption in a small percentage of patients [15]. Administration of systemic antibiotics may be necessary. 

Skin A severe acneiform eruption exacerbated by dantrolene sodimn has been reported [Tl J. 

Mowbray M, Sinclair SA, Allan SJ. Severe acneiform eruption exacerbated by dantrolene sodium. Clin Exp Dermatol 2009 34(2) 248-9. 

In 1996, nine workers from a Mexican chemical plant were evaluated for the effects of chronic exposure to mono-, ortho- and paradichlorobenzenes. They had a mean exposure of 24 working years and worked in all stages of chemical production. Safety equipment was not used, and direct contact with the chlorobenzenes occurred via the skin and respiratory tract. The nine workers had a polymorphic acneiform eruption consisting mainly of comedones and cysts. All had comedones on the face, predominately in the malar area lesions on the nose, axillae, chest, shoulders, arms, buttocks and thighs were also present. Yellow cysts (2-5 mm in diameter) were found on the malar area of the face, eyelids, penis, scrotum, chest, axilla... 

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