Acids cyclohexanoic

Synonyms Benzoic acid, hexahydro- Carboxycyclohexane Cyclohexancarboxylic acid Cyclohexanoic acid ... 

Synthesis. Both the cyclopentanoate drum composition, 3, and the cyclohexanoate drum, [n-BuSn(0)02CC6Hi1]g>, A> were prepared by a condensation reaction of n-butyl stannoic acid with the corresponding carboxylic acid, Equation 1. 

In the absence of ultrasound, the results show a substantial amount (49 %) of the dimer bicyclohexyl from the one-electron pathway, together with cyclohexylmethyl-ether, cyclohexanol and other products from the two-electron pathway (approx. 30%). The methyl cyclohexanoate ester (17%) can be thought to arise from the acid catalysed chemical esterification of the starting material with the solvent methanol. (As a result of the high current densities needed, (parasitic) discharge of the solvent methanol produces a large quantity of protons around the anode as a competitive reaction [54].)... 

A number of solvent extraction experiments have demonstrated that individual crown ethers in combination with a lipophilic sulfonic acid (such as didodecylnaphthalene sulfonic acid) are efficient, synergistic phase transfer agents for manganese(II) from aqueous solution into an organic phase." The X-ray structure of the manganese di-t-butylnaphthalenesul-fonate with cyclohexano-15-crown-5 ether as its toluene solvate has been reported." ... 

Two groups have investigated compounds containing the coumarin-4-acetic acid system (21). The 3,6,7-trimethyl derivative inhibited calf lens AR by 81 % at 1 x 10 4 M and caused a 21 % inhibition of sciatic nerve sorbitol accumulation in the streptozotocin-induced diabetic rat at 25 mg/kg given three times daily [50]. The 5,6-cyclohexano derivative had an IC50 value of 2 x 10 8 M for inhibition of rat lens AR but was not studied in vivo [51]. 

Use of esters of cyclohexanone polycarboxylic acids, such as di-(2-ethyl-hexyl) cyclohexanoic acid ester, enables production of materials having comparable mechanical properties with less PVC. It also increases UV stability, improves low temperature properties, and reduces smoke on burning. Highly flexible and semi-rigid goods can be manufactured with these plasticizers. This film is specially suitable for production of blood bags. 

DOP - di-(2-ethylhexyl) phthalate, DEHCH - Cg alcohol ester of cyclohexanoic acid, DDSIP -diisononyl phthalate, DINCH - diisononyl ester of cyclohexanoic acid, DIDP - diisodecyl phthalate, DfDCH - Cjo alcohol ester of cyclohexanoic acicf (PVC 100, plasticizer 50, CaCOj 10, LZB 320 2) (PVC 100, plasticizer DOP 50, DEHCH 50, DINP 53, DINCH 54.5, DIDP 55, DIDCH 57.5, LZB 722 2, ESBO 0.5)... 

Kumar, A., Mohapatra, P.K., and Manchanda, V.K. 1999. Extraction of strontium from nitric acid medium using di-t-butyl cyclohexano 18 crown 6 in 80% butanol-20% octanol mixture. Radiochim. Acta 85 113-117. 

Cyclohexane, 1-trifluoromethyl-1,2,2,3,3,4,4,5,5,6,6-undecafluoro-. See Perfluoromethylcyclohexane Cyclohexanoic acid. See Cyclohexanecarboxylic acid Cyclohexanol... 

Fig. 13 Product distribution for the Kolbe oxidation of cyclohexanoic acid [43] at different current densities both under (a) silent and (b) sonicated conditions.

In the first commercial plant (20,000 t/a), a cascade of stirred tank reactors are operated at 170°C between 10 and 17 bar. The catalyst (palladium supported on charcoal) is separated from the liquid product by centrifugation. Small amounts of catalyst are recovered at the bottom of the cyclohexanoe carboxylic acid distillation column. A plant of 100,000 t/a capacity is no in operation. 

A soln. of startg. epoxyketone in chloroform treated with 2 eqs. benzoic acid at room temp, for 30 h - product. Y 87.4%. The method is applicable to highly functionalized cyclopentano- and cyclohexano-analogs. E.s. T. Suzuki et al.. Heterocycles 27, 21-4 (1988). 

Not just limited to five-membered rings, the intramolecular Houben-Hoesch can be used to form rings of various sizes. The Patterson group synthesized cyclopentano, cyclohexano, and cycloheptano[a]pyrroles under Houben-Hoesch conditions using the Lewis acid Bp3-OEt2 followed by a... 

As shown in Scheme 2.8, the racemic starting acetate (A/B) is hydrolyzed to give alcohols (P/Q) in an organic medium containing a minimum amount of water, which in turn, by the action of the same lipase, are re-esterified with cyclohexanoic acid present in the mixture. Thus, the alcohol moiety of the substrate has to enter the active site of the lipase twice during the course of its transformation into the final product ester (R/S). An apparent selectivity of = 4(X) was achieved in this way, whereas the corresponding isolated single-step resolutions of this process were 1 = 8 for the hydrolysis of acetate A/B, and 2 = 97 for the esterification of alcohol P/Q with cyclohexanoic acid. 

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