Cyclohexanecarboxylic acid, acidity

Carboxylic acids, acyl chlorides, and sulfonyl chlorides used for deri-vatization of 4-aminophenylalanine and >-4-am i n op h e ny I a I a n i n e are as follows 5-hydantoinacetic acid, / ran, v - 4 - co t i n i n ec a r b o xy I i c acid, isonicotinic acid, 3-pyridinepropionic acid, 4-hydroxyphenylacetic acid, 2-butynoic acid, 2-pyrazinecarboxylic acid, cyclopropanecarboxylic acid, 3-hydroxy-2-qui-noxaline carboxylic acid, 5-bromovaleric acid, propargyl chloroformate, 3,4-dimethoxybenzoyl chloride, 2-thiophenesulfonyl chloride, 3-thiophene-carboxylic acid, 2-thiophenecarboxylic acid, 2-methylbutyric acid, 2-thio-pheneacetyl chloride, benzoic acid, furylacrylic acid, 4-nitrophenyl acetic acid, 2,5-dimethoxyphenylacetic acid, p-toluenesulfonyl chloride, 4-(di-methylamino)phenylacetic acid, 3-indolepropionic acid, phenoxyacetic acid, 3-(dimethylamino)benzoic acid, cyclohexanecarboxylic acid, naphtha-lenesulfonyl chloride, 4-bromophenylacetic acid, 4-bromobenzoic acid, 2-phenoxybutyric acid, 3,4-dichlorophenylacetic acid, (l-naphthoxy)acetic acid. 

As discussed above, when a S. avermitilis bkd mutant (lacking BCDH activity) is grown in a fermentation medium supplemented with the unnatural branched-chain fatty acid, cyclohexanecarboxylic acid (CHC), the novel CHC-derived av-ermectin, doramectin, is produced [34],... 

Triethylamine (8) Ethanamine, N,N-diethyl- (9) (121-44-8) p-Toluensulfonyl chloride (8) Benzenesulfonyl chloride, 4-methyl- (9) (98-59-9) (lS,2S)-2-(N-Tosylamino)cyclohexanecarboxylic acid Cyclohexanecarboxylic acid, 2-[[(4-methylphenyl)sulfonyl]amino]-, (1S-trans)- (12) (110456-11-6)... 

E.58) Cyclohexanecarboxylic acid, cyclohexanecarboxylic acid, hexahydrobenzoic acid, cyclohexylmethanoic acid, carboxycyclohexane [98-89-5]... 

Cyclohexaneacetic acid Cyclohexanecarboxylic acid Cyclohexanone Cyclohexyl acetate Cyclohexyl anthranilate Cyclohexyl butyrate Cyclohexyl cinnamate Cyclohexylethyl acetate Cyclohexyl formate Cyclohexyl isovalerate Cyclohexyl propionate Cyclopentanethiol Cyclopentanone p-Cymene trans-trans-2,4-Decadienal... 

Although turnover of the catalyst is low, even unreactive cyclohexane[526] and its derivatives are oxidatively carbonylated to cyclohexanecarboxylic acid using KiS Og as a reoxidant in 565% yield based on Pd(II)[527]. Similarly, methane and propane are converted into acetic acid in 1520% yield based on Pd(II) and butyric acid in 5500% yield [528],... 

N,N Dimethylcyclohexanecarboxamide A 500-ml three-necked flask is equipped with a reflux condenser (drying tube), a pressure-equalizing dropping funnel, and a magnetic stirrer. The flask is charged with 32 g (0.25 mole) of cyclohexanecarboxylic acid and thionyl chloride (45 g, 0.375 mole) is added over 5 minutes to the stirred acid. The flask is heated (oil bath) at a temperature of 150° for 1 hour. The reflux condenser is... 

Chemical Name trans-4-(aminomethyl)cyclohexanecarboxylic acid Common Name —... 

Ethyl 1-bromocyclohexanecarboxylate, when treated with magnesium in anhydrous ether-benzene with subsequent addition of cyclohexanone, yields ethyl l-(l-hydroxycyclohexyl)cyclo-hexanecarboxylate. Dehydration and saponification give rise to l-(l-cyclohexenyl)cyclohexanecarboxylic acid, which upon decarboxylation at 195° yields cyclohexylidenecyclohexane in 8% overall yield, m.p. 540.4 This olefin has also been prepared by the debromination of 1,1 -dibromobicyclohexyl with zinc in acetic acid. ... 

Carbonylation of alcohols to acids, table of examples, 46, 74 Carboxylation, by formic acid, 46, 74 of 2-methylcyclohexanol by formic acid-sulfuric acid to 1-methyl-cyclohexanecarboxylic acid, 46, 72... 

Cyclohexane, methylene-, 40, 66 Cyclohexanecarboxylic acid, 3,4,5-TRIACETOXY-, 42, 62 Cyclohexanecarboxylic acid, 3,4,5-iriol, 42, 62... 

Cyclohexane, methyl, 55, 112 CYCLOHEXANECARBOXYLIC ACID, 1 cyano-2-methyl-, ethyl ester, 55, 57 CYCLOHEXANONE, 2,3-epoxy- [7-Oxa-bityUo[4 1 0]heptan-2-one], 55, 52 2-Cyclohexen-l-one, 55, 52 5-Cyclohexene-l,4-dione, 2,3-dichloro-2,5-di-fm-butyl- [5-Cyclohexene-l,4-dione, 2,3-dichloro-2,5-bis( 1,1-di-methylethyl)-], 55, 32 5-Cyclohexene-l, 4-dione, 2,3,5-tnchloro-... 

The protocol is effective in preparation of hydrazides of 5 carbons or less. Cyclopropanecarboxylic acid hydrazide15 and isobutyric acid hydrazide16 were prepared from their corresponding acid chlorides in 64% and 71% yields, respectively. However, when this method was applied to cyclohexanecarboxylic acid chloride, the bis-acylhydrazide was the predominant product, and the mono-acylhydrazide17 was isolated in 25% yield.18... 

Cyclohexanecarboxylic acid hydrazide has low solubility in water. A biphasic mixture developed during the reaction, which led to the predominant formation of the bis-acylated material. 

Table 1. [53] Anodic decarboxylation of cyclohexanecarboxylic acid in different...

Dimethylamine (8) Methanamine, N-methyl- (9) (124-40-3) Methyl cyclohexanecarboxylate Cyclohexanecarboxylic acid, methyl ester (8, 9) (4630-82-4)... 

Blakley ER (1974) The microbial degradation of cyclohexanecarboxylic acid a pathway involving aromatiza-tion to form p-hydroxybenzoic acid. Can J Microbiol 20 1297-1306. 

Cyclohexanecarboxylic acid chloride, c351 Cyclohexaneethanol, c378 Cyclohexaneethyl acetate, c379 Cyclohexanemethanol, c384 Cyclohexanone cyanohydrin, hi 12 czis -4-Cyclohexene-l,2-dicarboximide, t82... 

The cyclohexanecarboxylic acid, m.p. 31-32°, purchased from Aldrich Chemical Company was used without further purification. 

A. cis- and trans-4-Aminocyclohexanecarboxylic acid. A mixture of 27.4 g. (0.20 mole) of />-aminobenzoic acid (Note 1), 200 ml. of water, and 2 g. of 10% rhodium-0.1% palladium on carbon ciitalyst (Note 2) is placed in a pressure bottle and hydrogenated at 50 p.s.i. When 0.6 mole of hydrogen has been absorbed (Note vl), the mixture is filtered and concentrated under reduced pressure until crystals start to form (Note 4). The mixture is diluted with 200 ml. of dimethylformamide and cooled to 5°, filtered, washed with dimethylformamide, then methanol, and amino-cyclohexanecarboxylic acid, m.p. 292-296° (Note 5). 

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