3.5- dichlorophenylacetic acid

Carboxylic acids, acyl chlorides, and sulfonyl chlorides used for deri-vatization of 4-aminophenylalanine and >-4-am i n op h e ny I a I a n i n e are as follows 5-hydantoinacetic acid, / ran, v - 4 - co t i n i n ec a r b o xy I i c acid, isonicotinic acid, 3-pyridinepropionic acid, 4-hydroxyphenylacetic acid, 2-butynoic acid, 2-pyrazinecarboxylic acid, cyclopropanecarboxylic acid, 3-hydroxy-2-qui-noxaline carboxylic acid, 5-bromovaleric acid, propargyl chloroformate, 3,4-dimethoxybenzoyl chloride, 2-thiophenesulfonyl chloride, 3-thiophene-carboxylic acid, 2-thiophenecarboxylic acid, 2-methylbutyric acid, 2-thio-pheneacetyl chloride, benzoic acid, furylacrylic acid, 4-nitrophenyl acetic acid, 2,5-dimethoxyphenylacetic acid, p-toluenesulfonyl chloride, 4-(di-methylamino)phenylacetic acid, 3-indolepropionic acid, phenoxyacetic acid, 3-(dimethylamino)benzoic acid, cyclohexanecarboxylic acid, naphtha-lenesulfonyl chloride, 4-bromophenylacetic acid, 4-bromobenzoic acid, 2-phenoxybutyric acid, 3,4-dichlorophenylacetic acid, (l-naphthoxy)acetic acid. 

Dichlorophenylacetic acid [6575-24-2] M 205.0, m 157-158 , pKcst -3.8. Crystd from aqueous EtOH. 

Guanfacin Guanfacin, A -amidmo-2-(2,6-dichlorophenyl)acetamide (22.3.2), is also synthesized in a very easy synthesis of reacting the acid chloride or ester of 2,6-dichlorophenylacetic acid with guanidine [4-7]. 

A benzathine-like dibase tran -AjA -dibenzyldiaminocyclohexane (B) crystallizes with four molecules of 2,3-dichlorophenylacetic acid (AH) as a stable conglomerate without a detectable partial solid solution. The crystal structure, resolved by single crystal X-ray diffraction, revealed an odd stoichiometry composed of B two A and two AH. (Figures 13.8 and 13.9)... 

Figure 13.9 Projection along the b axis of rra 5-A,AT-dibenzyldiaminocyclohexane -(2,3-dichlorophenylacetic acid)4. The green strips of rfoos thickness correspond to non-chiral layers of protonated acid. The white strips of 2xdoo3 thickness correspond to the chiral layers of the diammonium chiral organic base and the two deprotonated acids, adapted from ref 6.

J. Mahieux, S. Gonella, M. Sanselme and G. Coquerel, Crystal structure of a hybrid salt-cocrystal and its resolution by preferential crystallization ( ) (trans- N, N -dibenzyldiaminocyclohexaneX2, 3-dichlorophenylacetic acid)4. CrystEngComm, Submitted. 

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