Acid Acetic Fuming

D) No general reaction can be cited for the preparation of crystalline derivatives of Class (iii). Triphenylamine, when nitrated in acetic acid with fuming nitric acid, gives tri-/>-nitrophenylamine, m.p. 280°. The presence of substituents in the phenyl groups may however complicate or invalidate nitration. 

Nitration of 3-chloro-1,2-benzisoxazole gave the 5-nitro derivative (80ZC18, 79ZC452), as did nitration of l,2-benzisoxazole-3-acetic acid with fuming nitric acid. Under more forcing... 

Paint and varnish manufacturing Resin manufacturing closed reaction vessel Varnish cooldng-open or closed vessels Solvent thinning Acrolein, other aldehydes and fatty acids (odors), phthalic anhydride (sublimed) Ketones, fatty acids, formic acids, acetic acid, glycerine, acrolein, other aldehydes, phenols and terpenes from tall oils, hydrogen sulfide, alkyl sulfide, butyl mercaptan, and thiofen (odors) Olefins, branched-chain aromatics and ketones (odors), solvents Exhaust systems with scrubbers and fume burners Exhaust system with scrubbers and fume burners close-fitting hoods required for open kettles Exhaust system with fume burners... 

Cadinene dihydrobromide, C,5H24.2HBr, is obtained by shaking cad-ine dissolved in acetic acid with fuming hydrobromic acid. It forms white needles melting at 124° to 125°, and having a specific rotation — 36 13°. The dihydriodide, C15H24.2HI, prepared in a similar manner, melts at 105° to 106° and has a specific rotation - 48°. 

The reaction of alkynes with nitric acid or mixed acid is generally not synthetically useful. An exception is the reaction of acetylene with mixed acid or fuming nitric acid which leads to the formation of tetranitromethane. A modification to this reaction uses a mixture of anhydrous nitric acid and mercuric nitrate to form trinitromethane (nitroform) from acetylene. Nitroform is produced industrially via this method in a continuous process in 74 % yield. " The reaction of ethylene with 95-100 % nitric acid is also reported to yield nitroform (and 2-nitroethanol). The nitration of ketene with fuming nitric acid is reported to yield tetranitromethane. Tetranitromethane is conveniently synthesized in the laboratory by leaving a mixture of fuming nitric acid and acetic anhydride to stand at room temperature for several days. ... 

Diacetyl-orthonitric Acid (called Diacetyl-ortho- salpetersaure in Ger), (CH3COO)2N(OH)3 raw 183.12, N 7.65% col liq, bp 45° at 15mm, d L189 at 23°, nj 1.37542 formed by the action of coned HNO3 on acetic anhydride or by the action of acetic acid on fuming HNO3. 

N 9.79% 127.5° 132° readily sol in chlf less sol in Nitrobenz si sol in eth, glac acec ac 8c benz v si sol in ale petr eth insol in w was prepd from the nitrosonitro deriv by oxidizing in glac acet acid with fuming HNO3 (Refs 1 2)... 

Sodium isosorbide 5-nitrate, containing various different proportions of crystal water, was prepared in 46% yield by adding fuming nitric acid to isosorbide dissolved in a mixture of acetic acid, acetic anhydride, and ben-... 

Amino-3-nitrotoluene has been prepared by the nitration of oxalotoluide 4 and by the nitration of o-acetotoluide in acetic acid with fuming nitric acid 6 or with a mixture of nitric and sulfuric acid.3... 

The nitration of 1,2,3,5-tetraphenylpyrrole, using nitric acid acetic acid, gives the 4-nitro derivative (66MI1) as does 1-methyl-2,5-diphenyl-3-(2-pyridyl)pyrrole (9). The action of fuming nitric acid at 0°C on ethyl... 

Methyl-4-phenylsydnone is nitrated using nitric acid acetic acid at RT to give the 4-nitrophenyl product (80%), with small amounts (<3%) of ortho and possibly the meta product. The use of mixed acid, or fuming nitric acid, at 0°C forms the 2,4-dinitrophenyl product (60-70%) [62CI(L) 1718]. 

Nitration of derivatives of 9,10-dihydrolysergic acid with fuming nitric acid in acetic anhydride in the presence of urea has been reported (44a) to lead to the 2-nitro derivatives though only in 5-20% yield. 

This experiment uses corrosive glacial acetic acid and fuming nitric acid. Take special precautions and wear protective gloves when using these acids. A face shield is recommended when working with fuming nitric acid. 

SAFETY PROFILE A human poison by inhalation. Experimental poison by inhalation, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. Corrosive. A severe skin and eye irritant. An allergen and sensitizer. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, aUyl chloride, CS2, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO3, oleum, AgC104, H2SO4, p-propiolactone, or vinyl acetate. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx and NH3. See also AMINES. 

Combustible when exposed to heat or flame. Can react with oxidizing materials. Explosive reaction with acetic acid + acetic anhydride + ammonium nitrate + nitric acid, 1-bromopenta borane(9) (above 90°C), iodoform (at 178°C), iodine (at 138°C). Reaction with nitric acid + acetic anhydride forms the military explosives RDX and HMX. Reacts violently with Na202. When heated to decomposition it emits toxic fumes of formaldehyde and NOx. See also AMINES. 

OSHA PEL CL 5 mg(Mn)/m3 ACGIH TLV TWA 5 mg(NIn)/m3 DOT CLASSIFICATION 5.1 Label Oxidizer SAFETY PROFILE Probably a severe irritant to the skin, eyes, and mucous membranes. A powerful oxidizer and fire hazard. Explosive reaction with acetic acid, acetic anhydride. Reacts vigorously with combustibles. When heated to decomposition it emits toxic fumes of Na20. See also MANGANESE COMPOUNDS, PERMANGANATES, and POTASSIUM PERMANGANATE. 

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