Achyrocline flaccida

Only very few flavones of this type exist, in most cases showing various other types of substituents as well. (9-prenylation is known to occur at position 6, 7, or 4 -OH. Most of the substituents are 3,3-dimethylallyl structures. Whereas epoxyprenyl derivatives have been reported from the aerial parts of Achyrocline flaccida (Asteraceae), a new compound with 4 -0-dimethylallyl substitution was later reported from the leaves of Ficus maxima (compound 128, Table 12.3). There is no indication of external accumulation in any of the plants listed. Millettocalyxin B (compound 129, Table 12.3) from the stem bark of Millettia ery-throcalyx represents an example of a mixed structure (methylenedioxy- and (9-prenylsubstitu-tion). Similarly, ovalifolin (compound 131, Table 12.3) has a furano-substitutent in addition and is being reported for two new sources of Fabaceae. The name ovalifolin (published 1974) has priority for this furanoflavone its use for a structurally different compound from Ehretia ovalifolia is, therefore, obsolete. 

As a result of the intensive search for antiviral substances from medicinal plants, antiviral activity against HSV was found in extracts from Cedrela tubiflora Bertoni, leaves [79], from Prunella vulgaris L., a perennial plant commonly found in China, the British Isles and Europe [80] and from Trichilia glabra L. leaves [81]. Phytochemical studies indicate that these plants contain anionic PS as active constituents which may inhibit HSV by competing for cell receptors as well as by some unknown mechanisms after the virus has penetrated the cells. Furthermore, the in vitro antiviral activity demonstrated by extracts of the medicinal plant Achyrocline flaccida (Weinm.) D.C. on HSV-1 is exerted early during viral replication, essentially during viral adsorption to host... 

Fig. (3). 7,4 Dihydroxy 5-methoxy flavanone and 4,2 ,4 -trihydroxy 6 -methoxychalcone from Achyrocline flaccida.

A polysaccharide Exhibited activities against HSV Achyrocline flaccida Garcia et al. (1999)... 

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