Acetylcysteine for

CHUNG F L, KELLOFF G, STEELE V, PITTMAN B, ZANG E, JIAO D, RIGOTTY J, CHOI C I and RiVENSON A (1996) Chemopreventive efficacy of arylalkyl isothrocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats . Cancer Res, 56 772-8. 

Kshirsagar AY Poole C, Mottl A, et al. N-acetylcysteine for the prevention of radiocontrast induced nephropathy a metaanalysis of prospective controlled trials. J Am Soc Nephrol 2004 15 761-769. 

Redondo, P. and Bauza, A., Topical N-acetylcysteine for lamellar ichthyosis, Lancet, 354, 1880, 1999. 

Howard, R.J., Blake, D.R., Pall, H., Williams, A., Green, I.D. (1987). Allopurinol/N-acetylcysteine for carbon monoxide poisoning. Lancet ii 628-9. 

Birck R, Krzossok S, Markowetz F, Schnulle P, van der Woude FJ, and Braun C. 2003. Acetylcysteine for prevention of contrast nephropathy meta-analysis. Lancet 362 598-603. 

Fung JW, Szeto CC, Chan WW, et al. 2004. Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency a randomized trial. Am JKidney Dis 43 801 -808. 

Kay J, Chow WH, Chan TM, et al. Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention a randomized controlled trial. JAMA 2003 289 553-558. 

Specifio drugs or antidotes may be available for systemic toxicity of some hydrocarbons (eg, acetylcysteine for carbon tetrachloride and methylene blue for methemoglobin formers) or their solutes (eg, chelation therapy for leaded gasoline and antidotes for pesticides, etc). 

A. Metoclopramide is used to prevent and control persistent nausea and vomiting, particularly when the ability to administer activated charcoal (eg, treatment of theophylline poisoning) or other oral antidotal therapy (eg, acetylcysteine for acetaminophen poisoning) is compromised. 

The hypothesis that the ageing-related increase in the risk of heart disease may be causally related to the ageing-related shift in plasma thiol/disul-phide redox state is supported by several clinical studies on W-acetylcysteine (for review see Droge 2002). 

Agnihotri N, Mishra PC (2009) Mechanism of scavenging action of N-acetylcysteine for the OH radical a quantum computational study. J Phys Chem B 113 12096-12104 Li P, Shen Z, Wang W, Ma Z, Bi S, Sun H, Bu Y (2010) The capture of H" and OH" radicals by vitamin C and implications for the new source for the formation of the anion free radical. Phys Chem Chem Phys 12 5256-5267... 

Chung, F.L., Kelloff, G., Steele, V., Pittman, B., Zang, E., Jiao, D., Rigotty, J., etal. 1996. Chemo-preventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lungtumorigenesis in Fischer rats. Cancer Research, 56(4), 772-8. 

Abbreviations used Cya = cysteamine H3NCH2CH2—, Cys = cysteine HOOCCH(NHj )CH2—, Pen = penicillamine H00CCH(NH3 )C(CH3)2 ACys = A -acetylcysteine. For the alternative assignment of this signal to... 

Berwanger O, Cavalcanti AB, Sousa AM, Buehler A, CasteUo-Junior HJ, CantarelU MJ, et al. Acetylcysteine for the prevention of renal outcomes in patients with diabetes meUitus undergoing coronary and peripheral vascular angiography a substudy of the acetylcysteine for contrast-induced nephropathy trial. Circ Cardiovasc Interv. 2013 Apr 6(2) 139-45. 

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