3- Acetyl-l-benzyl

Aziridin 3-Acetyl-l-benzyl-2,2-dimethyl- E16c, 442 (Br-C-C-Br + Amin)... 

The reduced form of the respiratory coenzyme diphosphopyridine nucleotide (DPNH), which is vitally important for all cellular metabolism, is changed by dilute acid to a substance that, in the light of the following model experiments, may be a covalent hydrate. The 1,4-and 1,6-dihydro derivatives of l-benzylpyridine-3-carboxamide furnish a single substance when dissolved in dilute acid at 20° and the solution is basified. The stable yellow product, which has a prominent peak at 292 nm, was assigned the constitution 1-benzyl-6-hydroxy-1,4,5,6-tetra-hydropyridine-3-carboxamide61 (see Scheme 2). 3-Acetyl-1 -benzyl- 1,4-... 

Acetyl-l-benzyl-3,4,4a,5,6,7-hexahydro-l,5-naphthyridine-2,7(l//)-dione (15) (a byproduct from a primary synthesis) appears to have undergone partial dehydrogenation and N— (9-transacylation to afford 7-acetoxy-l-benzyl-3,4-dihydro-1,5-naphthyridin-2( 1 //)-one (16) (Pd/C, xylene, 130°C, 30 h ... 

Acetyl-l-benzyl-5-hydroxy-3,4,7,8-tetrahydro-l, 7-naphthyridin-2(l //)-one (10) underwent catalytic dehydrogenation and rearrangement to give 5-acetoxy-3,4-dillydro-l,7-naphthyridin-2(l//)-one (11) (Pd/C, xylene, 135°C, 30 h 45%).1272... 

SAA1853>, and this can be illustrated, for instance, by the structural elucidation of a palladium(ii) complex with the oxime of (L)-3-acetyl-5-benzyl-l-phenyl-4,5-dihydro-l,2,4-triazin-6-one <2000H(53)1737>. 

Piperidines. A benzene soln. containing equivalent amounts of N-benzyl-3-bromopropylamine and methyl vinyl ketone refluxed 1 hr., then treated at reflux with an equivalent of K-tert-butoxide 3-acetyl-l-benzylpiperidine. Y 50%,... 

A mixture of 6-amino-l-benzyl-5-hydroxyuracil, acetic anhydride, and anhydrous Na-acetate refluxed under Ng until a clear soln. results 6-acetamido-5-acetoxy-3-acetyl-l-benzyluracil (Y 80-90%) dissolved in ice-cold ethanol satd. with NHg, and allowed to stand 0.5 hr. 6-acetamido-l-benzyl-5-hydroxyuracil (Y almost 100%). S. Bien, D. Amith, and M. Ber, Soc. Perkin I 1973, 1089. 

Ricinus communis.—The specific intermediates between nicotinic acid and ricinine are unknown a reasonable biosynthetic pathway is illustrated in Scheme 10. Robinson and co-workers have obtained a crude enzyme from R. communis seedlings, and resolved it by chromatography on DEAE-cellulose into three components, all of which catalysed the oxidation of 3-cyano-l-methylpyridinium perchlorate (43) to the pyridones (46) and (47). The optimum activity for ail these fractions was between pH 9.S and 10.S. The enzymes were relatively non-specific. All the following pyridinium salts were oxidized 3-formyl-l-methylpyridinium iodide, 3-nitro-l-methylpyridinium iodide, 3-acetyl-l-methylpyridinium iodide, 3-cyano-l-ethylpyridinium iodide, and l-benzyl-3-cyanopyridinium chloride. N-Methylnicotinamide, trigonelline sulphate, 1-methylpyridinium iodide, nicotinic acid, 1-methylquinolinium iodide, and 3-cyanopyridine, were not oxidized to any appreciable extent. 

Imtdazo[4,5-d]pyridaztne, l-benzyl-4,7-dtchloro-nucleophtlic displacement reactions, 5, 629 Imidazo[l,5-6]pyridazine-5,7(3H,6H)-dione, 4-acetyl-2-phenyl-synthesis, 5, 651 Imidazo[l, 2-6]pyridazines reactions, 5, 628 synthesis, 5, 650 Imidazo[ 1,5-6]pyridazines synthesis, 5, 651 Imidazo[4,5-c]pyridazines reactions, 5, 628-629 synthesis, 5, 651 Imidazo[4,5-d]pyridazines reactions, 5, 629 synthesis, 5, 436, 468, 651-652 3H-Imidazo[l,2-6]pyridazin-2-one, 6-chloro-3-dichloromethylene-synthesis, 3, 355... 

Bruce and Sutcliffe obtained l-acetyl-2-methyl-3-phenylindole (123) by the action of acetyl chloride on 2-methyl-3-pheiiylindole magnesium iodide in ether.These authors were able to obtain l-benzoyl-2-benzyl-3-phenylindole (124) but not l-acetyl-2-benzyl-3-phenylindole (125) from 2-benzyl-3-phenylindole magnesium iodide by analogous procedures.3-Acetyl-2-phenylindole (126) and 3-propionyl-2-pheny]indole (127) have recently been prepared in fair yield by the acylation of 2-phenylindole magnesium iodide with acetyl and propionyl chloride, respectively. Le ete obtained a mixture of l-acetyl-3-ethylindole (128) and 2-acetyl-3-ethylindole (129) by the interaction of acetyl chloride with 3-ethylindole magnesium iodide in ether. 

Isoquinoline, 2-acetyl-l, 2,3,4-tettahydro-6,7-dimethoxy-l-inethylene-, 4 Isoquinoline, 2-benzoyl-l -benzy 1-1-cyano-1,2-dihydro- [1-Isoquinolinecarbo-mtrile, 2-benzoyl-l, 2-dihydro-l -(phenjlmethyl)-), 23 Isoquinoline, 2-benzoyl-l -cyano-1,2-di-hydro l-Isoquinohnecarbomtrile, 2-ben2oyl-l, 2-dihydro-], 20 ISOQUINOLINE, 1-BENZYL- [ISOQUINOLINE, HPHENYLMFTHYL)-], 19 Isoquinoline, 3,4-dihydro-6,7-dimethoxy-l-methyl-, 4... 

Dihydro-2(l,3-dimethyluracil-5-yl)-l,3,4-oxadiazole was obtained in 53% yield by the [3+2] cycloaddition of diazomethane to the formyl group of l,3-dimethyl-5-formyluracil <1997T7045>. The reaction of l-acetyl-2-benzyl-hydrazine with methyl glyoxalate in toluene afforded an oxadiazolidine derivative <1996TL4323>. 

The reaction of l-benzyl-4-(acetylimido)-l/7-[l,2,4]triazolium inner salt 120 (an azomethine imine) with aromatic isothiocyanates yields among other products 5-acetyl-6-(arylimino)-l,5,6,7-anhydro[l,2,4]triazolo[3,4-A][l,3,4]thiadia-zoles 121 (Equation 34) <1984CCC1713>. 

The amidic group in methyl A -acetyl-p-aminobenzoate was reduced preferentially to an ester group with borane in tetrahydrofuran (1.5-1.8 mol per mol of the amide), giving 66% yield of methyl p-A -ethylaminobenzoate. Similarly l-benzyl-3-methoxycarbonyl-5-pyrrolidone afforded methyl l-ben2yl-3-pyr-rolidinecarboxylate in 54% yield and l,2-diethyl-5-ethoxycarbonyl-3-pyra-zolidone gave ethyl l,2-diethylpyrazolidine-3-carboxylate in 60% yield. 

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