3-Acetyl-1-benzyl

The reduced form of the respiratory coenzyme diphosphopyridine nucleotide (DPNH), which is vitally important for all cellular metabolism, is changed by dilute acid to a substance that, in the light of the following model experiments, may be a covalent hydrate. The 1,4-and 1,6-dihydro derivatives of l-benzylpyridine-3-carboxamide furnish a single substance when dissolved in dilute acid at 20° and the solution is basified. The stable yellow product, which has a prominent peak at 292 nm, was assigned the constitution 1-benzyl-6-hydroxy-1,4,5,6-tetra-hydropyridine-3-carboxamide61 (see Scheme 2). 3-Acetyl-1 -benzyl- 1,4-... 

Aliphatic-Substituted Acetylated benzylic a, 0, 7 7-CH2OH 7-CH2OAc Methoxyl Acetoxyl Aromatic Aliphatic... 

The only example of an ozonide (5) was reported (85LA2116) when ozone was used instead of photooxidation 5 was also converted into 2-benzopyrylium via the corresponding o-acetyl benzyl ketone 3, but not... 

The benzylidene derivative (94) has been converted into the alcohol (95) [97, 98] using the diborane — trimethylamine — aluminium chloride reagent [99] and into the diol (96) [95, 100, 101]. Veyrieres has converted methyl P-lactoside (and the corresponding allyl lactoside) into the 3-O-allyl ether (97) in good yield [102] by alkylation of the dibutylstannylene derivative in the presence of tetrabutylammonium iodide [103, 104], and this was converted into the alcohol (98) and the triol (99) [105]. Veyrieres [106] has also converted (97) into the per-p-bromobenzyl derivative and deallyl-ated the product to give a derivative with a free 3 -hydroxyl group. The diol (100) [107] has been converted by the stannylation procedure [108, 109] into the alcohol (101) [110, 111]. The partially acetylated benzyl P-lactoside (103) [101,112, 113] has been converted into the alcohol (104) via the orthoacetate [113]. 

Ballou, Roseman and Link43 have reported that, on catalytic hydro-genolysis, the 0-acetylated benzyl D-glucopyranoside, D-xylopyranoside,... 

Disulfan Acetyl-benzyl- IX, 53 Dithiobenzoesaure 3,5-Dimethyl-4-hydroxy- E5, 900 (ArOM + CS2) Dithiokohlensaure -O-ethylester-S-phenylester IX, 818... 

Pentryl. See 2-(2 , 4, 6-TrInitro-N-nitranilino Ethanol Nitrate under Aniline ethanol and Derivatives A425-L to A42 )-R Pentryl Homologs A429-R Peracetic Acid, Benzylester. See Acetyl-benzyl peroxide A55-L P hen acyl Azide. See a>-Azido acetophenone under Acetophenone A47-R Phenazone. See Antipyrine A471-R Phenetidine. See Aminophenetole A240-R Phenyl Abietate. See under Abietic Acid A4rL... 

Fuganti s synthesis of serine (Scheme 19) relied on the stereospecific conversion of [l,l- H2]-2-phenylethylamine 68 to (1S)-[1- H,3-2-phenyl-ethanol 69 by Willia anomala (88). Acetylation, benzylic bromination, and... 

The STaz moiety was found stable toward common protecting group manipulations involving basic and acidic conditions, for example, acetylation, benzylation, acetal formation and cleavage, etc. (77). The STaz derivatives were found to be stable toward hydrolysis in the presence of acidic thiophilic reagents. Thus, comparative hydrolytic stability studies showed that STaz glycosides are even more stable than their 1-5-ethyl and 1-5-phenyl counterparts in the presence ofNBSorNlS/TfOH. 

Cerny, M. et al, Coll Czech. Chem. Comm., 1968, 33, 1143-1156 (p-D-pyr 2,4-ditosyl, -d-pyr 3-Ac 2,4-ditosyl, jl-D-pyr tri-Ac, -D-pyr benzyl tosyl, fl-D-pyr benzyl, j3-D-pyr acetyl benzyl tosyl)... 

CgH.oNOj]- Acetyl benzyl nitroxide H5C6CH2NCOCH3 Photochemical reaction of CH3CHO + CgHjCH NO/ CfiHe EPR/ 333 2.0065 (2) iSf 0.75 H(CH2) 0.50 68Macl... 

Methoxyethyl glycosides bearing such protecting groups as acetyl, benzyl and allyl may be cleaved by treatment with TiCl, in dichloromethane followed by hydrolysis on a column of silica gel. ... 

Pentosyl disaccharides continue to be of interest - largely because of their occurrence in natural products. The cyclic 6-0- 3-/)-arabinopyranosyl- -D-glucopyanose compound (123) heis been isolated from Lonicera nitida, and 6-0-/3-D-xylopyranosyl-(3-l>-glucose has been obtained as the hexa-O-acetyl benzyl glycoside from the acetylated aqueous extracts of green fruit of Prunus laurocerasus ... 

Acetyl Benzyl — 162-164 -8(H2 0) Meindl and Tuppy (1965a 1966a)... 

Pungent odour. Formic acid, acetic acid, acetyl chloride, acetic anhydride, benzoyl chloride, benzyl chloride, pyridine. Benzoquinone (when warmed with water). 

The ketones are readily prepared, for example, acetophenone from benzene, acetyl chloride (or acetic anhydride) and aluminium chloride by the Friedel and Crafts reaction ethyl benzyl ketones by passing a mixture of phenylacetic acid and propionic acid over thoria at 450° and n-propyl- p-phenylethylketone by circulating a mixture of hydrocinnamic acid and n-butyric acid over thoria (for further details, see under Aromatic Ketones, Sections IV,136, IV,137 and IV,141). 

In a later paper Knowles and Norman compared more fully nitrations of benzylic compounds in acetyl nitrate and in mixed acid (table 5.9), and interpreted the results in terms of three factors nitronium ion nitration in both media some degree of protonation of the oxygen... 

Ph.CH2.OMe, Ph.(CH2)2.0Me, Ph.(CH2)3.0Me (2-3, 3-4, 1-3), does not decrease steadily, but goes through a maximum. These two circumstances point to a specific -interaction in nitrations of the ethers with acetyl nitrate which is important with benzyl methyl ether, more important with methyl phenethyl ether, and not important with methyl phenpropyl ether. This interaction is the reaction with dinitrogen pentoxide already mentioned, and the variation in its importance is thought to be due to the different sizes of the rings formed in the transition states from the different ethers. 

The phenolic hydroxyl group of tyrosine, the imidazole moiety of histidine, and the amide groups of asparagine and glutamine are often not protected in peptide synthesis, since it is usually unnecessary. The protection of the hydroxyl group in serine and threonine (O-acetylation or O-benzylation) is not needed in the azide condensation procedure but may become important when other activation methods are used. 

Acetyl-5-chloro-3-phenyl Ethyl 2-benzyl-3-oxobutanoate Cone. H Cl 50-90 [7]... 

Ethylenediamine (70,71), benzyl alcohol and acetone (72), ethylene glycol (73) and C2—C g carboxyUc acids (74) are claimed to increase the reactivity of cellulose toward acetylation. Sodium hydroxide and Hquid ammonia (71) are excellent swelling agents and have been used to activate cellulose before esterification. Ultrasonic treatment of cellulose slurries (75) reportedly swells the fibers and improves reactivity. 

Cinnolin-3(2//)-one (7) is methylated with diazomethane or methyl sulfate to give 2-methylcinnolin-3(2H)-one. In a similar manner, benzylation with benzyl chloride, cyanoethylation with acrylonitrile in the presence of benzyltrimethylammonium hydroxide and glucosidation with tetra-O-acetyl-a-o-glucopyranosyl bromide in the presence of a base affords the corresponding 2-substituted cinnolin-3(2//)-ones. However, glucosidation of the silver salt of cinnolin-3(2//)-one produces the corresponding O-substituted compound. 

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