3- Acetyl-2-amino-4-hydroxy

More examples where a hydrotropic aqueous medium was used under typical green conditions in Friedlander s quinoline method have been reported (07MI279). 3-Acetyl-2-amino-4-hydroxy-l, 3-pentadienecarboni-trite 5 was used for the preparation of 2-(2-amino-3-cyano-6-hydroxyphe-nyl)-8-cyano-5-hydroxy-4-methyl-quinoline 6 based on the transformation of hydroxyvinyl ketone to the diphenylboron chelate and condensation of the latter with dimethylformamide (DMF) and dimethy-lacetal (DMA) (Scheme 3) (97RCB122). 

D-fMO MO-Nonitol, 2,6-anhydro-3,S,7-trideoxy-l-C-([hydroxy-(tetrahydro-2-methoxy-5,6-dimethyl-4-methylene-2 H-pyran-2-yl) acetyl] amino)-5,5-di methyl-1, S,9-tri-0-rriethyl-, 2R-[2( j(,2[S (5-q], 5P,6P] -... 

Benzo[6]thiophene, 2-acetyl-3-hydroxy-synthesis, 4, 892 Benzo[6]thiophene, 2-acyl-synthesis, 4, 918 Benzo[6]thiophene, 3-acyl-synthesis, 4, 918- 19 Benzo[6]thiophene, acylamino-synthesis, 4, 815 Benzo[6]thiophene, alkenyl-synthesis, 4, 917 Benzo[6]thiophene, 2-alkoxy-synthesis, 4, 929 Benzo[6]thiophene, 3-alkoxy-synthesis, 4, 929 Benzo[6]thiophene, 4-alkoxy-synthesis, 4, 930 Benzo[6]thiophene, 2-alkyl-synthesis, 4, 877-878 Benzo[6]thiophene, 2-alkylthio-synthesis, 4, 931 Benzo[6]thiophene, 2-amino-diazotization, 4, 810 reactivity, 4, 797 stability, 4, 810 synthesis, 4, 869, 924-925 tautomerism, 4, 38 Benzo[6]thiophene, 3-amino-cycloaddition reactions, 4, 68 synthesis, 4, 109, 881, 925 Benzo[6]thiophene, 4-amino-synthesis, 4, 925 Benzo[6]thiophene, 5-amino-synthesis, 4, 925 Benzo[6]thiophene, 7-amino-synthesis, 4, 925 Benzo[6]thiophene, 3-t-amyl-synthesis, 4, 915 Benzo[6]thiophene, 2-aryl-synthesis, 4, 881... 

Furan, 3-acetoxy-2,4,5-triphenyl-synthesis, 4, 659 Furan, 2-acetyl-isopropylation, 4, 607 rotamers, 4, 544 synthesis, 4, 665 toxicity, 1, 136 Furan, 3-acetyl-bromination, 4, 604 Furan, 3-acetyI-2-amino-reactions, 4, 74 Furan, 2-acetyl-3,5-dimethyl-synthesis, 4, 691 Furan, 2-acetyl-5-ethyl-synthesis, 4, 691 Furan, 2-acetyl-3-hydroxy-synthesis, 4, 649... 

Chemical Name 6-[ [ [ [(4-Hydroxy-1,5-naphthyridin-3-yl)carbonyl] amino] -phenyl acetyl] -amino] -3,3-dimethyl-7-oxo4-thia-1 -atabicydo[3.2.0] -heptane-2-carboxylic acid... 

The solubility of (S) 3,5-dichloro-2-hydroxy-[[2-[[[3-hydroxy-5[l, 4,5,6-tetrahy-dro-5-hydroxypyrimidin-2-yl-amino]phenyl]carbonyl]amino]acetyl]amino]-benzene-propanoic acid and its monohydrate was measured at several temperatures in different aqueous acetonitrile solvent systems [7]. The data were fitted to a frame-... 

Acetyltransferases catalyze the acetylation of amino, hydroxyl, and thiol functional groups. Acetylation of hydroxy and thiol groups is comparatively rare and of much less importance in alkaloid metabolism than reactions with amino functional groups. The types of amines that are acetylated include arylamines (the major route of metabolism in many species), aliphatic amines, hydrazines, sulfonamides, and the a-amino group of cysteine conjugates. The purification, physical properties, and specificity of the N-acetyltransfereases have been reviewed (116-118). 

Silylation or (trifluoro) acetylation of hydroxy- or amino groups... 

Ceftriaxone Ceftriaxone, 7-[[(2-amino-4-lhiazolyl)-2-(Z)-(methyoximino)acetyl]amino]-8-oxo-3-[[(l,2,5,6-tetrahydro-2-methyl-5,6-dioxo-l,2,4-triazin-3-yl)thio]methyl]-5-thia-l-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.72), is synthesized by acylating 7-amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-l,2,4-triazin-5-on-3-yl)thio]methyl]3-cefem-... 

Cyclocondensations of benzylidenemalononitrile with pyridinethiones 210 and 211 afforded the amino derivatives of pyrido[2,l-h][l,3]thiazines 212 and 213, respectively (90MI2 92MI6). Reaction of 5-acetyl-3-cyano-6-methyl-4-phenyl-3,4-dihydropyridine-2(lfl)-thione with epichlorohydrin in the presence of potassium hydroxide and sodium methylate gave 7-acetyl-3-hydroxy-6-methyl-8-phenyl-2,3,4,8-tetrahydropyrido[2,l-h][l,3]-thiazine-9-carbonitrile (94KGS139). 

Moxalactam disodium is a drug entity which was discovered at Shionogi and Company, Limited, Osaka, Japan, and codeveloped with Eli Lilly and Company. The drug is marketed under the trade names of MOXAM and LAMOXAM . The chemical entity is the disodium salt of (6R,7R)-7-[[carboxy(4-hydroxy-phenyl)-acetyl]amino]-7-methoxy-3-[[l-methyl-lH-tetrazole-5-yl)thio]-methyl]-8-oxo-5-oxa-l-azabi cyclo[4.2.0]oct-2-ene-2-carboxyli c acid. 

By action HN03/H2S04 on 4-chlorophenylarsonic acid is obtained 4-chloro-3-nitrophenylarsonic acid which is converted at 100°C with 33% aqueous solution of sodium hydroxide to 4-hydroxy-3-nitrophenylarsonic acid. After reduction of N02 group of 4-hydroxy-3-nitrophenylarsonic acid by the action of Na2S203 or Fe/NaOH is obtained 3-amino-4-hydroxyphenylarsonic acid. From 3-amino-4-hydroxyphenylarsonic acid and acetic anhydride is prepared N-acetyl-4-hydroxy-m-arsanilic acid. 

Chemical Name 1(2H)-Pyrimidineacetamide, N-((lS,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-l-(phenylmethyl) pentyl)tetrahyrdo-a-l-methylethyl)-2-oxo-, (aS)-... 

Methyl 7-acetamido-4-oxo-1,4-dihydro-1,8-naphthyridine-2-carboxylate Methyl l-acetyl-4-hydroxy-2-oxo-l,2-dihydro-1,8-naphthyridine-3-carboxylate Methyl 2-amino-5,7-dimethyl-1,8-naphthyridine-... 

Other kinds of modifications may be necessary to convert a newly synthesized protein to its biologically active form. The N-formyl group of the initiating methionine in prokaryotes is removed by a deformylase. A methionine amino-peptidase removes the initiating residue in many eukaryotic proteins. Other posttranslational modifications may include acetylation, amidation, hydroxy lation, methylation, phosphorylation, and sulfation of specific amino acid resi-... 

Hydroxylamine converts pyran-2-ones into pyridine JV-oxides by attack at the 1,2-bond for example, the pyran-2-one (278), obtained by heating 3-acetyl-4-hydroxy-6-methyl-pyran-2-one (dehydroacetic acid) and DMF dimethyl acetal in xylene, reacts with two moles of hydroxylamine under mild conditions to give the pyrano[2,3-6]pyridine JV-oxide (279) (77JHC931). Hydrazine converts pyran-2-ones into l-amino-2-pyridones (78JHC759). 

Pentendisaure 4-(Amino-morpho-lino-methylen)-2-cyan- -1-ethylester-5-nitril E15/2, 2198 [OR - C(CN) = C(NH2)-NR2] Pteridin 6-Butanoyl-2,4-dioxo-l,3,7-trimethyl-1,2,3,4-tetrahydro-E13/2, 1318 (Acylierung) IH-Tetrazol 5-[(4-Acetyl-3-hydroxy-... 

A halo acid, p-(/S-bromoethyl)-benzoic acid (87%), a hydroxy acid, yS-hydroxyisovaleric acid (9%), and an acetylated amino acid, p-(/3-acetyl-aminoethyl)4>enzoic acid (78%), have been made by this method. Attempts to prepare 3-nitro- and 4-hydroxy-benzoic acids from the corresponding acetophenones have failed. Oxidation of the methylene group of 2-acetylfluorene occurs during the reaction to give fluorenone-2-car-boxylic acid (60%). ... 

Sakami, W., and G. Toennies The Investigation of Amino Acid Reactions by Methods of Non-aqueous Titrimetry. II. Differential Acetylation of Hydroxy-Groups and a Method for the Preparation of the O-Acetyl Derivatives of Hydroxy Amino Acids. J. biol. Chem. 144, 203 (1942). 

Allyliden-l-ethenyl- 2233, 2234 7- [Benzyl-(2,2-diphenyl-acetyl)-amino]-methyl -4-hydroxy- 1742... 

Acetyl(2-hydroxy-3-meth-03gTpropyI)amino)-iy,JV -bis(2,3-dihydro3g ropyl)-... 

Ahnlich der Reaktion von 3(5)-Amino-lH-pyrazolen mit 3-Oxo-alkansaure-estern verlauft die Umsetzung mit 4-ChLorcarbonyl-3,5-dimethyl-l,2-oxazolen als Dicarbonyl-Aquivalent. Nach Acylierung des 3(5)-Amino-lH-pyrazols und Offnung des 1,2-Oxazol-Rings werden 6-Acetyl-5-hydroxy-7-methyl-[Pg.682]

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