Diflorasone 17,21-diacetate

Bis(acetyloxy)-6a,9-difluoro-llb-hydroxy-16b-methylpregna-l,4-diene-3,20-dione. See Diflorasone diacetate. 

The diflorasone is reacted with orthoacetic acid trimethyl ester in the presence of toluene sulfonic acid to give diflorasone diacetate. 

C24H3iFO. 50763-89-8) see Diflorasone diacetate 21-acetoxy-3 0-dioxo-6a-fluoro-l 1 P-hydroxy- 16a-methyl-4-pregnene... 

C25Hi2F20ft 50630-18-7) see Diflorasone diacetate (6ot,llp,l tx,17a)-6,9-difluoro-ll-hydroxy-16-methyl 3-oxo-17-(l>oxopropoxy)andro5ta>l,4-diene>17 carbothioic acid... 

Diflorasone diacetate Cream, Ointment (emollient base) 0.05%... 

Diflorasone diacetate Psorcon cream, oint 0.05% Ultrahigh... 

Betamethasone dipropionate cream, ointment 0.05% Clobetasol propionate cream, ointment 0.05% Diflorasone diacetate 0.05%... 

Betamethasone valerate ointment 0.1% Diflorasone diacetate cream 0.05% Ttiamcinolone acetonide ointment 0.1%, cream 0.5%... 

Diflorasone Diacetate Cream For corticosteroid responsive dermatoses... 

Experimental studies on the percutaneous absorption of hydrocortisone fail to reveal a significant increase in absorption when applied on a repetitive basis and a single daily application may be effective in most conditions. Ointment bases tend to give better activity to the corticosteroid than do cream or lotion vehicles. Increasing the concentration of a corticosteroid increases the penetration but not proportionately. For example, approximately 1% of a 0.25% hydrocortisone solution is absorbed from the forearm. A 10-fold increase in concentration causes only a fourfold increase in absorption. Solubility of the corticosteroid in the vehicle is a significant determinant of the percutaneous absorption of a topical steroid. Marked increases in efficacy are noted when optimized vehicles are used, as demonstrated by newer formulations of betamethasone dipropionate and diflorasone diacetate. 

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