2-acetoxy acetyl chloride

Ethoxyacetamide (Athoxyacetamid or Athyl-atherglykolsaureamid, in Ger), C2H5O.CH.2CONH2 mw 103.12, N 13-58% plates (from benz) mp 82.5°(sublimes), bp 225° at 75mm Hg easily sol in w, ale, eth, benz and CS2. It can be prepd by action of aqueous ammonia on ethyl ester of ethoxy-acetic acid or by action of ammonia on acetoxy-acetyl chloride in ether... 

Commerpon and his collaborators also reported a diastereoselective condensation of a chiral imine 7.1.6 with acetoxy acetyl chloride (7.1.7). Reaction gave a pair of diastereomers, with the desired one 7.1.8 in 50-60% diastereomeric excess. After cleavage of the acetate, cis-/ -lactam... 

Alkoxythiazoles are prepared by heterocyclization (274, 462). The Williamson method using catalytic amounts of KI and cupric oxide is also possible (278. 288, 306). 5-Acetoxy-4-alkenylthiazoles are obtained by treatment of 242 with acetyl chloride and triethylamine or with acetic anhydride and pyridine (450). Similarly, the reaction of diphenylketene with 242 affords 5-acyloxy-4-alkenylthiazoles (243) (Scheme 120) (450). The readiness of these o-acetylations suggests that 4-alkylidene thiazoline-5-one might be in equilibrium with 4-alkenyl-5-hydroxythiazoles (450). 

Aminosodium salt and acylated with 1 H-tetrazole-1 -acetyl chloride. The acetoxy group is then displaced by reaction with 5-methyl-1,3-4-thi-adiazole-2-thiol in buffer solution. The product acid is converted to the sodium salt by NaHCOa. 

The most simple l, 4-dithiocin system, which is stable, is the 6-acetoxy derivative 13, which can be synthesized from 1,4-dithiocin-6(57/)-onc (12) by trapping its enolate with acetyl chloride.7 9... 

Preparative hazards have been noted for the following compoimds 4-Acetoxy -3 -methoxy-2-nitrobenzaldehyde, 3266 Acetyl chloride, 0735 Aluminium copper(I) sulfide, 0084... 

The acetoxy group of 9-(l-acetoxyethyl)carbazole is easily displaced with alcohols. Easy displacement of a similarly situated halogen can be achieved, as has been noted before (see Section II,C,2) thus methanol converts 9-(l-chloro-2-iodoethyl)carbazole to 9-(2-iodo-l-methoxyethyI) car-bazole. Elimination of acetic acid or ethanol by strongly heating 9-(l-acetoxyalkyl)- or 9-(l-ethoxyalkyl)carbazoles gives 9-vinylcarbazoles. In the absence of acid, ( )-alkenes are produced, but acid catalysis leads to a mixture of E and Z isomers. Acetyl chloride in pyridine also effects ethanol elimination. ... 

Acetonitrile, phenyl-, 55,91, 94 Acetonitrile-18-crown-6 complex, 57, 31 Acetophenone, 58, 57, 61 ACETOPHENONE, 2-(2-ACETAMIDO-ETHYLE4,5-DIMETHOXY-, 56, 3 Acetophenone, 2-(2-acetamidoethyl)-4,5, 6-trimethoxy-, 56, 7 Acetophenone, 4-chloro, 55, 40 Acetophenone, 4-chloro-, oxime, 55, 39, 40 7-Acetoxy-4,4,6,7-tetramethylbicyclo-[4 2 0] octan-2-one, 57, 113 Acctylacetone, 58, 52, 56 Acetyl chloride, a rert-butyl-o-cyano-, 55, 38... 

Golden (28) unsuccessfully attempted to prepare polymers by elimination of acetyl chloride and acetic anhydride from p-acetoxy-chlorobenzene and diacetoxybenzene, respectively. He was also unable to dehydrate hydroquinone. In the course of his study on the dehydration of phenols to aromatic ethers over thoria, Briner (8) also attempted, unsuccessfully, to dehydrate the polyphenols pyrocatechol, resorcinol and hydroquinone. 

The stirred mixture of (15,41 )-ds -4-acetoxy-2-cyclopenten-l-ol (2) (5.0 g 35 mmol) and pyridine (4.18 g, 6.95 mmol) in dichloromethane (100 mL) is treated at 0°C with commercially available D3-acetyl chloride (3.44g 42mmol). The mixture is allowed to reach room temperature within 12 h and is then treated twice with 1M HC1 (50 mL), saturated aqueous NaHC03 and NaCl. The organic phase is dried over MgSC>4, the solvent is removed, and the crude product is purified by... 

Dashkevich and Kuvaeva121 assumed that the products arising from 63 (R = H, Me) with acetyl chloride or />-nitrobenzoyl chloride were 4-acyloxy-2-oxo-2//-pyrido[l,2- ] pyrimidines. This assignment is not likely to be correct, however, for Kato and Masuda167 demonstrated that the 2-acetoxy (215 mp = 143 C) and the 3-acetyl (216 mp = 210 C) derivatives were formed from the sodium salt of 63 (R = H) with acetyl chloride. The acet-ylated product obtained by Dashkewich and Kuvaeva from 63 (R = H) melted at 152-154 C, and thus it might well have been 215 or a mixture of 215 and 216. 

Acetoxy-a,j3-dibromochalcone, 32, 75 Acetylacetone, 31, 43 9-AcrTYLANTHRACENE, 30, 1 Acetylation, of 2-/>-acetylphenylhydro-ciuinnne, 34, 1 of hydrogen sulfide, 31, 105 o -Acetyl-y-butyrolactone, 31, 74 Acetyl chloride, 30, 1... 

An iron-catalyzed multicomponent reaction of aldehyde 4a, acetophenone, acetyl chloride and acetonitrile, which was used as the solvent, gave P-amino ketones such as 32 (Scheme 8.11) [41]. It was assumed that the sequence starts with an aldol reaction of aldehyde and ketone and then proceeds further with a displacement of a P-acetoxy group by the nucleophilic nitrile-nitrogen. 

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