Acetone Gramicidin

The combined crystal crops were redissolved In 50 ml absolute acetone, and the solution refrigerated overnight. After filtering, the formed crystals were dried in vacuo. The total yield of crystalline gramicidin thus obtained was 2.5 g. 

Dr. Synge noted that when gramicidin complex was crystallized from acetone, he obtained small... 

Gramicidin A [Bacillus brevis] 1883.33 methanol, ethanol, pyridine, acetone antibiotic peptide ionophore forming channels for and alkali cations... 

Actibomycin. Actinomycin A (164,170), CM-nHia-ssNT-sOs-in m.p. 250 C., red platelets, [ ]b — —320°, absorption peaks at 2400 and 4500 A soluble in acetone, alcohol, benzene, 10% hydrochloric acid slightly soluble in water and ether insoluble in dilute acids, dilute alkalies, and petroleum ether. It is readily reduced by sodium hydrosulfite and by stannous chloride but not by sodium bisulfite. Several groups can be acetylated. It seems to be a quinone containing free hydroxyl groups. Oxford (120) thinks that it may not be a true para quinone and that it might contain a polypeptide chain, like gramicidin, as well as a chromo-... 

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