Acetates Acetazolamide

Acetanilides, benzoyl-colour couplers in colour photography, 1, 372 Acetanilides, pivaloyl-colour couplers in colour photography, 1, 372 Acetazolamide — see l,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-Acetic acid, acetamidocyano-ethyl ester, 1, 307 Acetic acid, 2-acylphenyl-isochroman-3-one synthesis from, 3, 858 Acetic acid, 3-benzo[6]thiophenyl-biological activity, 4, 912 Acetic acid, l,2-benzoxazol-3-yl-electrophilic substitution, 6, 48... 

Acetic anhydride Acetaminophen Acetazolamide Acetrizoate sodium Acetyl cysteine Acetyl sulfisoxazole Afloqualone... 

BOROHYDRIDE REDUCTION ACETAZOLAMIDE Acetic acid, autoprotolysis constant, AUTOPROTOLYSIS ACETOACETATE DECARBOXYLASE Acetoacetate decarboxylase reduction, BOROHYDRIDE REDUCTION ACETOLACTATE SYNTHASE Acetone,... 

Acetazolamide Acetazolamide is 5-acetamido-l,3,4-thiadiazole-2-sulfonamide (9.7.5). The synthesis of acetazolamide is based on the production of 2-amino-5-mercapto-l,3, 4-thiadiazole (9.7.2), which is synthesized by the reaction of ammonium thiocyanate and hydrazine, forming hydrazino-N,N -( ji-(thiourea) (9.7.1), which cycles into thiazole (9.7.2) upon reaction with phosgene. Acylation of (9.7.2) with acetic anhydride gives 2-acetylamino-5-mercapto-l,3,4-thiadiazol (9.7.3). The obtained product is chlorinated to give 2-acetylamino-5-mercapto-l,3,4-thiadiazol-5-sulfonylchloride (9.7.4), which is transformed into acetazolamide upon reaction with ammonia (9.7.5) [24,25]. 

Methazolamide Methazolamide, N-(4-methyl-2-sulfamoyl-l,3,4-thiadiazol-5-yliden) acetamide (21.2.3), is made by an intermediate product of acetazolamide synthesis— 2-acetylamino-5-mercapto-l,3,4-thadiazol (9.7.3). This is benzylated with benzylchloride at the mercapto group, forming 2-acetylamino-5-benzylthio-l,3,4-thiadiazole (21.2.1). Further methylation of the product with methyl iodide leads to the formation of N-(4-methyl-2-benzylthio-l,3,4-thiadiazol-5-yliden)acetamide (21.2.2). Oxidation and simultaneous chlorination of the resulting product with chlorine in an aqueous solution of acetic acid, and reacting the resulting chlorosulfonic derivative with ammonia gives (21.2.3) [5-7]. 

Acetamidosalicylic acid, 994 Acetaminophen, 849 Acetmiilide, 312 Acetarsol, 313 Acetarsol sodium, 313 Acetarsone, 313 Acetate buffer (pH 5), 1169 Acetazolam, 313 Acetazolamide, 313 Acetazolamide sodium, 313 Acetazoleamide, 313 Acetcarbromal, 317 Acethydrocodone, 1007 Acetic acid, 314, 1169 (metabolite), 312, 851 Acetic acid, concentrated, 314 Acetic acid, dilute, 1169 Acetic acid, glacial, 314 Acetic aldehyde, 311 Acetic anhydride, 188 Acetic ether, 602 Acetohexamide, 314 Acetomenadione, 315 Acetomenaphthone, 315 Acetomorphine, 524... 

SYNS 2-ACETAMIDO-5-SULFONAMIDO-l,3,4-THIADIAZOLE ACETAMDOTHIADIAZ-OLESL LFONAMIDE ACETAMOX ACETAZOL-AMID ACETAZOLAMIDE ACETAZOLEAMIDE ACETOZALAMIDE 2-ACET LAMINO-l,3,4-THIADIAZOLEA-SULFOXAMIDE N-(5-(AMINO-... 

The ophthalmic drugs that have been the most frequent causes of product liability and negligence claims are antiglaucoma drugs (i.e., acetazolamide, echothio-phate iodide) and steroids (i.e., hydrocortisone, dexa-methasone sodium phosphate, and prednisolone acetate). 

The documentation of all of these interactions is very limited, and their incidence is uncertain. Concurrent use should be monitored for the possible development of osteomalacia or altered antiepileptic levels and steps taken to accommodate them. Withdraw the acetazolamide if necessary, or ad-just the dosage of the antiepileptic appropriately. In the case of the children with rickets the acet olamide was withdrawn and high doses of vitamin D was given. It seems possible that other carbonic anhydrase inhibitors may behave like acetazolamide. 

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