Acetamide diisopropyl

Diisopropyl ether, see Isopropyl ether Dimethoxymethane, see Methylal Dimethyl acetamide Dimethylamine... 

Diethyl ketone Diethyl phthalate Difluorodibromomethane Diglycidyl ether (DGE) dl Dihydroxybenzene, see Hydroquinone Diisobutyl ketone Diisoctyl phthalate Diisodecyl phthalate Diisononyl phthalate Diisopropyl ether Diisopropylamine Di-linear 79 phthalate Dimethoxymethane, see Methylal Dimethyl acetamide Dimethylamine... 

Acetamide N.N-Diisopropyl Flnoro-phenyl- ElOa. 488 (H - F) t,4H20KM)2... 

Irreversible inhibitors often provide clues to the nature of the active site. Enzymes that are inhibited by iodo-acetamide, for example, frequently have a cysteine in the active site, and the cysteinyl sulfhydryl group often plays an essential role in the catalytic mechanism (fig. 7.18). An example is glyceraldehyde 3-phosphate dehydrogenase, in which the catalytic mechanism begins with a reaction of the cysteine with the aldehyde substrate (see fig. 12.21). As we discuss in chapter 8, trypsin and many related proteolytic enzymes are inhibited irreversibly by diisopropyl-fluorophosphate (fig. 7.18), which reacts with a critical serine residue in the active site. 

Nanda KK, Nolt MB, Cato MJ, Kane SA, Kiss L, Spencer RH, Jixin Wang J, Lynch JL, Regan CP, Stump GL, Li B, White R, Yeh S, Bogusky MJ, Bilodeau MX, Dinsmore CJ, Lindsley CW, Hartman GD, Wolkenberg SE, Trotter BW. Potent antagonists of the atrial lKur/Kvl.5 potassium channel synthesis and evaluation of analogous Ai,Af-diisopropyl-2-(pyridine-3-yl)acetamides. Bioorg. Med. Chem. Lett. 2006 16 5897-5901. 

Diisopropyl benzene 1,4-Diisopropyl benzene Dimethyl acetamide Dimethylaminomethyl phenol Dimethylaminotrimethylsilane... 

After the successful elaboration of the 6,7,7-ring system of colchicine, the only remaining synthetic operation was the installation of the acetamide moiety. Alcohol 267 was allowed to react with diisopropyl azodicarboxylate... 

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