Accuracy, factors affecting

RMC can be selectively extracted into butyl acetate. Concentration coefficient 50 was achieved. Factors affecting accuracy and reproducibility of the proposed method were investigated. Method is simple and fast. Detection limit is 0,3 p.g/1 for P(V). 

To develop robust methods, you have to keep in mind that simple methods are preferable. Also, if you have a chromatographic background, then the factors affecting CE precision (and to a lesser extent accuracy) are widely different to HPLC, which is currently the predominantly employed technique for drug assay. There is no general preference for the choice between techniques CE, LC, or other. The choice should be made on a scientific basis, supported by the relative merits of the techniques for the specific problem and factors such as the experience of the method-developing scientist. Robust CE methods have been successfully transferred to relatively inexperienced QC and Contract Research Organisation (CRO) labs. 

This chapter deals with the validation of capillary electrophoresis (CE) methods. It describes the various validation characteristics, namely accuracy, precision, specificity, detection limit, quantitation limit, linearity, and range in accordance with the official guidelines. Practical aspects related to the calculation of these parameters and factors affecting them in CE analysis have also been described. Validation requirements have been described according to the goal of the method. The chapter contains numerous tables and diagrams to illustrate these ideas. It also covers other related aspects such as instrument qualification, revalidation, and method transfer. 

This work describes the design, operation and application of the continuous GPC viscosity detector for the characterization of the molecular weight distribution of polymers. Details of the design and factors affecting the precision and accuracy of results are discussed along with selected examples of polymers with narrow and broad molecular weight distribution. 

Some of the most important factors affecting the precision and the accuracy of 14 MeV activation are reviewed below. The random errors as listed in the section on precision are generally reduced in importance by running replicate analyses on each of several aliquants of the sample and averaging all the results. Consideration given to the reduction of these sources of error will, of course, result in a reduction of the number... 

Grob, K., Jr., and Neukom, H. P. (1980). Factors affecting the accuracy and precision of cold on-column injections in capillary gas chromatography. J. Chromatogr. 189, 109-117. 

Problems in the determination of the surface area of active phases can arise from a number of sources. An overestimation of the amount of active surface can be caused by spillover of the adsorbing species on the support, solubility in the adsorbent, subsurface oxidation (when using O2 or N20), or as a result of additional physical adsorption on the support. The extent to which these factors affect the accuracy of the results depends on the nature of the active phase, the support, and the conditions of the experiment. Problems can occur with adsorptives which may corrode the surface. For example, CO can remove Ni atoms from the surface of small Ni particles even at ambient temperatures. 

The methodology developed to date has led to a marked improvement in the accuracy with which release rates can be measured from hollow fiber formulations. A careful combination of methods such as the combined use of the airflow and extraction methods discussed here with the appropriate combination of quantification methods will ultimately lead to a better understanding of the various factors affecting the release of materials from controlled release devices. 

In addition, the occurrence of isobaric interferences of analyte ions with isobaric polyatomic ions can hamper the accuracy and precision of isotope ratio measurements (see also Section 6.1.3). The main factors affecting the accurate and precise determination, for example, of using ICP-MS, are the isobaric interference of the molecular ion on 236pj+ analyte ions, and... 

The most problematic factor affecting accuracy in QPA via XRD is that of microabsorption. While the application of whole pattern, Rietveld based techniques for may allow for the correction of some sample related... 

Campbell, C. A., Paul, E. A., Rennie, D. A., and McCallum, K. J. (1967a). Factors affecting the accuracy of the carbon-dating method in soil humus studies. Soil Sci. 104, 81-85. 

Blumenthal, R.N., A technical presentation of the factors affecting the accuracy of carbon/oxygen probes, in Proc. of the Second Int. Cortf. on Carburising and Nitriding with Atmospheres, Cleveland, OH, 6-8 December 1995, 17—23. 

When attempting to determine the movement of an oil slick, two factors affect accuracy. The more significant factor is the inability to obtain accurate wind and current speeds at the time of a spill. The other, very minor factor is a phenomenon... 

So many factors affect the accuracy of bond distances and bond angles derived from rotational constants that nearly every molecule is a unique case. Nevertheless, there are several key questions that should be answered by every report of structural analysis from rotational spectra. Some of these are as follows ... 

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