Accumulation controlled feed

Figure 7.14 Conversion curves obtained with the optimized linear feed and with the accumulation controlled feed time (h).

The condition for the practical implementation of such a feed control is the availability of a computer controlled feed system and of an on-line measurement of the accumulation. The later condition can be achieved either by an on-line measurement of the reactant concentration, using analytical methods or indirectly, by using a heat balance of the reactor. The amount of reactant fed to the reactor corresponds to a certain energy of reaction and can be compared to the heat removed from the reaction mass by the heat exchange system. For such a measurement, the required data are the mass flow rate of the cooling medium, its inlet temperature, and its outlet temperature. The feed profile can also be simplified into three constant feed rates, which approximate the ideal profile. This kind of semi-batch process shortens the time-cycle of the process and maintains safe conditions during the whole process time. This procedure was shown to work with different reaction schemes [16, 19, 20], as long as the fed compound B does not enter parallel reactions. 

In general the operation of exothermic irreversible series reactions, may result in run-a-ways and low selectivity. This behavior may be counteracted by staged (controlled) feeding of reactants. In the concept studied here, accumulated reactant A must desorb from the sorbent before it can react on the catalyst surface. 

Distribution of the scoured wool to the cards then occurs. This is often done using a combination of pneumatic and mechanical transport systems, usually with the provision of accumulator bins that hold a few hour s production. Modem cards are usually fed with tower feeds, which automatically control the height of the wool column. 

The feed flow is often not controlled but is rather on level control from another column or vessel. The liquid product flow s (distillate and bottoms) are often on level rather than flow control. Top vapor product is, however, usually on pressure control. The reflu.x is frequently on FRC, but also may be on column TRC or accumulator level. 

Transgenic E. coli accumulate comparatively low levels of carotenoids " compared to microbial algae, yeasts, and bacteria. Many efforts ° have focused on increasing accumulation by manipulation of factors affecting metabolic flux and metabolite accnmnlation (listed and discnssed in Sections 5.3.1.1 and 5.3.1.3 A) and have been reviewed." - " In bacterial systems, approaches to control can be categorized as either infrastructural (plasmids, enzymes, strains) or ultrastructural (media and feeding, enviromnent, precursor pools, substrate flux). 

Coke builds up on the catalyst since the start up of operation. In the first weeks of operation, an amount between 5% and 8% of coke accumulates on the catalyst. The rate of deposition decreases with time on stream, a careful monitoring of temperature and of feed/H2 ratio is the basis for controlling deposition. Coke deposition primarily affects the hydrogenation reactions (and so denitrogenation), but the deposition rate determines the catalyst life. As mentioned above, deactivation is compensated by an increase in temperature (and some times in pressure, when denitrogenation has to be adjusted, as well). However, increasing severity, increases coke deposition and shorten catalyst life. 

Feed-forward control is more likely to be focused on a reaction occurring at or near the end of a pathway. Compounds produced early in the pathway act to enhance the activity of the control enzyme and so prevent a back log of accumulated intermediates just before the control point. An example of feed-forward control is the action of glucose-6-phosphate, fructose-1,6-bisphosphate (F-l,6bisP) and phosphoenol pyruvate (PEP), all of which activate the enzyme pyruvate kinase in glycolysis in the liver. 

However, once the controller performance is reestablished, the percentage of methane produced is recovered. On the other hand, the response of the VFA concentration along E3 is illustrated in Figure 11b. Observe that the response of the VFA at the beginning of E3 is similar to that obtained in El and E2 whereas the response becomes oscillating after pure vinasses are feed to the process. Nevertheless, there are not signs of a maintained accumulation of VFA during the experiment. 

---