Accelerated Development Strategies

Accelerated Development Strategy Objective Focus Analysis Features... 

Such testing is part of the development strategy and is normally carried out under more severe conditions than those used for accelerated testing. 

Nine strategies consistently appear in LC/MS-based methods for accelerated development (Table 5.1). The nine strategies are standard methods, template structure identification, databases, screening, integration, miniaturization, parallel processing, visualization, and... 

The nine strategies form a powerful set of tools to devise, construct, and refine pharmaceutical analysis methods. The proactive use of a single strategy, or the combination of several, produces unique information and inspires new perspectives on analysis. In this way, analysis methods create new mechanisms for information gathering, rather than passively waiting for a sample to be generated. And in this way LC/MS analysis capabilities partnered with samplegenerating disciplines to create new accelerated development opportunities. 

Key reasons, to include contract manufacturing into the development strategy, are to increase cash flow/minimize fixed assets by avoiding investments into manufacturing facilities, and to accelerate the drug development by creating access to additional expertise. 

To achieve significant market penetration, fuel cell vehicles will have to meet or exceed the performance baseline established by today s spark-ignition engine vehicles. These performance criteria include improved gas mileage, rapid acceleration, and turn-key start-up. The goal of this work is to develop strategies that will result in demonstration of a fuel processor for fuel cell vehicles that starts rapidly. The Department of Energy has set a start-up time of 30 seconds (from 20°C to maximum power) for the year 2010. 

In both of these pieces of apparatus, isothermal operation and optimum membrane area are obtained. Good temperature control is essential not only to provide a value for T in the equations, but also because the capillary attached to a larger reservoir behaves like a thermometer, with the column height varying with temperature fluctuations. The contact area must be maximized to speed up an otherwise slow equilibration process. Various practical strategies for presetting the osmometer to an approximate n value have been developed, and these also accelerate the equilibration process. 

---