Abortifacients prostaglandins

Gemeprost (73 16.16-dimethvl-trans-A -prostaglandin-E]) is dramatically more potent on a dosage basis as an abortifacient than prostaglandin E2 itself and has fewer side effects. The gem-dimethyl groups at C-16 protect the alcohol moiety at C-15 from rapid metabolic oxidation. 

Therapeutic Function Oxytocic abortifacient Chemical Name 11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid Common Name Prostaglandin E2, PGE2 Structural Formula o... 

Dinoprostone (Cervidil Vaginal Insert, Prepidil Vaginal Gel, Prostin E2) [Prostaglandin/Abortifacient] WARNING Should... 

F. Role in therapy According to Micromedex, oxytocin is routinely used for the induction of labor at term and postpartum for the control of uterine bleeding. Oxytocin is not the drug of choice for induction of labor for abortion. Oxytocin infusion has been used following prostaglandin or hypertonic abortifacients to shorten the induction to abortion time when inducing second-trimester abortion, inducing abortion when a patient has failed to respond to the abortifacient, or to induce abortion after membranes have ruptured. 

Mifepristone, an antagonist at progesterone and glucocorticoid receptors, has a luteolytic effect and is effective as a postcoital contraceptive. When combined with a prostaglandin it is also an effective abortifacient. 

Misoprostol, an analogue of PGE1 is licensed for use in the management of gastroduodenal ulceration. It is an effective myometrial stimulant of the pregnant uterus and is used for the induction of labor and as abortifacient, both alone and in combination with other substances (for example mifepristone). It provides an effective alternative to gemeprost, the most widely used prostaglandin pessaries in combination with mifepristone. 

Spilman, C. Roseman, T. Luteolytic and abortifacient effects in rhesus monkeys of silicone vaginal rings containing 15(S) 15-methyl-prostaglandin F2 alpha methyl ester. Contraception 1975, 11, 409-18. 

Its main use is in extracorporeal procedures, such as kidney dialysis. It has a very short lifetime in the body, though it can be given by continuous infusion in vivo. epoprostenol sodium epoprostenol. epOStane [ban. inn, usan] (Win 32729) is a synthetic prostaglandin carbonitrile derivative antiprogestogen, which has been investigated for use as an abortifacient and OXYTOCIC AGENT, and to induce labour. gppyTM M adrenaline. 

Prostaglandins are mostly used as abortifacients. They may be administered by vaginal suppository (Dinoprostone, which... 

Abortifacient A drug used to cause an abortion. Example Prostaglandin Fp ... 

Although Ci5-methylation has given prostaglandins with dramatically enhanced effects as orally active, long lasting inhibitors of gastric acid secretion (159) and to a lesser extent as abortifacients (160). this modification has proven to be a major dissapointment for the development of improved bronchodilators. 

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