Oxytocic agents

Drug interactions Co-administration of dinoprostone in patients receiving intravenous oxytocic agents such as oxytocin may result in uterine hyperstimulation and is therefore contraindicated. Severe hypertension has been reported when oxytocin was given 3 to 4 hours following prophylactic administration of a vasoconstrictor in conjunction with spinal anesthesia. Oxytocin may enhance the neuromuscular blockade of succinylcholine. 

Its main use is in extracorporeal procedures, such as kidney dialysis. It has a very short lifetime in the body, though it can be given by continuous infusion in vivo. epoprostenol sodium epoprostenol. epOStane [ban. inn, usan] (Win 32729) is a synthetic prostaglandin carbonitrile derivative antiprogestogen, which has been investigated for use as an abortifacient and OXYTOCIC AGENT, and to induce labour. gppyTM M adrenaline. 

OXYTOCIC AGENTS hasten childbirth, generally by contracting the uterus. Many therapeutically useful agents do... 

Tetramethylputrescine (tetramethyl-l,4-diaminobutane) has been isolated. This species was known to be in use as an oral oxytocic agent in African folk medicine. 

Ergonovine is a water-soluble lysergic acid derivative that occurs in ergot. It is used as an oxytocic agent. Its maleate derivative is used in the treatment of postpartum hemorrhage. 

Sparteine occnrs in yellow and black lupin beans (Lupinus luteus L. and L. niger). It also occnrs in other Lupinus species as well as in Cytisus and Spartium species. Therapentically, it is used as an oxytocic agent. 

Vasicine, 9, from Adhatoda vasica, is currently being tested in Phase I clinical studies in India as an oxytocic agent - i.e., to initiate contractions in childbirth and to reduce post-partum bleeding (66). 

Sparteine was withdrawn by the U.S. FDA as an injectable drug because of its ability to produce titanic uterine contractions and its unpredictability. Due to the tyramine content of the herb, use may cause blood pressure crisis with simultaneous administrations of MAO inhibitors (blumenthal 1) due to the ability of the herb to increase the tonus of the gravid uterus, use is contraindicated in pregnancy sparteine is a potent oxytocic agent broom tops is also contraindicated in patients with high blood pressure (newall wichtl). The oral LD50 of sparteine in mice is 220mg/kg. ... 

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