Abbokinase - Urokinase

Abbokinase (Urokinase) Pulmonary embolism Human kidney cells... 

Abbokinase (Urokinase for injection). Abbott Laboratories, Abbott Park, IL. Acthar Gel (Corticotropin injection). Rhone Poulanc Rorer, Collegeville, PA. 

Abbott Abbokinase (urokinase Ischemic events Expired Expired... 

Urokinase (Abbokinase) For PE, 4,400 international units/kg IV over 10 minutes followed by 4,400 international units/kg/hour for 12 to 24 hours. / Alteplase (Activase) For PE, 100 mg by IV infusion over 2 hours. 

Urokinase Urokinase is an enzyme that is extracted from human urine or kidney cells [46-55], which directly cleaves specific peptide bonds, in particular the Arg-560-Val-561 bond in the plasminogen molecule, thus transforming it into plasmin. It is used for the same indications as streptokinase. Synonyms of this drug are abbokinase and others. 

Streptokinase (Streptase, Kabikinase) Tenecteplase (TNKase) Urokinase (Abbokinase)... 

Urokinase (Abbokinase) is a two-polypeptide chain serine protease that does not bind avidly to hbrin and that directly activates both circulating and hbrin-bound plasminogen. The plasma half-life of urokinase is approximately 10 to 20 minutes. Urokinase is derived from human cells and thus is not anhgenic. Urokinase produces a signihcant resolution of recent pulmonary emboli. 

Urokinase is also a thrombolytic agent, used for treating pulmonary embolism. Two variants of this protease have already been isolated one of 54 kDa and another of 33 kDa, both displaying proteolytic activity over plasminogen. Until recently, the only exogenous source for this enzyme was urine. However, in 2002 the product called Abbokinase, which is produced in neonatal kidney tissue culture, was approved in the USA. 

Abbokinase Eudurase urokinase Ischaemic events Abbott Expired... 

Jftoral uracil/tegafur urokinase Abbokinase, Ukidan... 

The normal tissue lysis activators are proteins. One such activator from the kidney is urokinase. This enzyme has not been found systemically, but only in the kidney and urine. It directly activates plasminogen to plasmin by hydrolysis of a small peptide from the plasminogen molecule. Other known enzymatic activators are streptokinase and brinase, which have been discussed elsewhere.82>83 Urokinase can be isolated from urine in small amounts. This has made it a very expensive material. Abbott Laboratories has developed a tissue culture technique in which kidney cells are grown under exacting conditions and urokinase is isolated.84 Recently Abbott Laboratories made a request to the FDA for a license to sell this form of urokinase called Abbokinase . This process should increase the availability of urokinase and decrease its cost. 

Its main weakness is decreased potency due to antibody formation. The use of urokinase, which is not antigenic, has been limited due to supply problems and cost of manufacture from urine. However, the problem may have been solved due to a new source from kidney tissue culture (Abbokinase ). 

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