A-Isopropylacrylamide

CH3)2CH0H + CH2=C=0 CH3C00CH(CH3)2 and the Ritter reaction to prepare A/-isopropylacrylamide [2210-25-5] from acrylonitrile [107-13-1] and isopropyl alcohol ... 

J. P. Baker and R. A. Siegel, Poly(A-isopropylacrylamide) hydrogel membranes for pulsatile drug delivery, Proc. Int. Symp. Control Release Bioact. Mater, 22, 340-341 (1995). 

Kaneko, Y, Sakai, K., Kikuchi, A., Yoshida, R., Sakurai, Y, and Okano, T. Influence of freely mobile grafted chain length on dynamic properties of comb-type grafted poly(A-isopropylacrylamide) hydrogels. Macromolecules, 1995, 28, 7717-7723. 

Okano, T, Yamada, N., Sakai, H., and Sakurai, Y. A novel recovery system for cultured cells using plasma-treated polystyrene dishes graphted with poly(A-isopropylacrylamide), J. Biomed. Mater. Res., 1993, 27, 1243-1251. 

Chung, J. E., Yokoyama, M., Suzuki, K., Aoyagi, T., Sakurai, Y, and Okano, T. Reversibly thermo-responsive alkyl-terminated poly(A-isopropylacrylamide) coreshell micellar structures. Colloids Surfaces (B Biointerfaces), 1997, 9, 37-48. 

Winnik, F. M., Davidson, A. R., Hamer, G. K., and Kitano, H. Amphiphilic poly(A-isopropylacrylamide) prepared by using a lipophilc radical initiator Synthesis and solution properties in water. Macromolecules, 1992, 25, 1876-1880. 

Brazel, C. S. and Peppas, N. A. Synthesis and characterization of thermo- and chemomechanically responsive poly(A-isopropylacrylamide-co-methacryhc acid) hydrogels. Macromolecules 1995, 28, 8016-8020. 

Lower Critical Solution Ihmperatures of Aqueous Copolymers of A-Isopropylacrylamide and Other A-Substituted Acrylamides... 

Note 3 An example of covalent polymer gels is nei-poly(A-isopropylacrylamide) swollen in water, which shows volume phase transition during heating. 

Since acrylamide-based monoliths generally represent polar support materials, they are predominately also used for separation in normal-phase mode. For that purpose, monolithic polymers were prepared by polymerization of mixtures containing piperazine diacrylamide as cross-linking agent and methacrylamide, A-isopropylacrylamide or 2-hydroxyethyl methacrylate, and vinylsulfo-nic acid as monomers. 

Figure 30 Temperature dependence of the permeability (P) of polyethylene glycol molecules for A-isopropylacrylamide (NIPAAm) grafted films. Polyethylene glycol with four kinds of masses (1 x 10, 1x10, 2x10, 7x10" ) are contained in the solution.

Coexistence of Phases and the Nature of First-Order Phase Transition in Poly-A-isopropylacrylamide Gels... 

Several attempts have been made to construct stimuli-responsive polymer solution and gel systems which undergo isothermal phase transitions by external stimulation, such as photons or chemicals. Aqueous solutions of poly(A -isopropylacrylamide) having photoisomerizable chromophores or host molecules in the pendant groups showed reversible phase separations by photoirradiation or by the addition of specific metal or ammonium ions. The gels made of the polymers also underwent photostimulated or chemical-induced volume phase transitions. 

Fig. 5. Poly(A-isopropylacrylamide) gel swelling vs temperature. Circles are data points amt the solid fine is the lattice model prediction with one fitted parameter. (Reprinted with permission from [12], 1990 American Chemical Society)...

Cussler EL (1989) Isolation process using swellable poly(A-isopropylacrylamide) gels. U.S. Pat. 4,863,613... 

In contrast to these approaches based on nonspecific interactions, Zhang and coworkers described a molecularly imprinted hydrogel based on the ther-moresponsive PNIPAM [184], This hydrogel was prepared by copolymerization of a metal chelate monomer iV-(4-vinyl)-benzyl iminodiacetic acid, which formed a coordination complex with the template protein in the presence of Cu ions, A-isopropylacrylamide, acrylamide, and IV.lV-methylenebisacrylamide as crosslinker. The interaction of the imprinted thermoresponsive hydrogel with the protein could be switched between coordination effects and electrostatic attraction by addition or omission of Cu ions. Furthermore, this imprinted hydrogel allowed switching of lysozyme adsorption by changing the temperature. 

RODS Poly(A-isopropylacrylamide) (PIPAAm) NIH-3T3 fibroblasts Electron beam activated polymerization of 2-carboxy-iV-isopropylacrylamide through a mask on PIPAAm (or vice versa), subsequent NHS mediated binding of peptide to carboxyl functional groups 2007 [173]... 

Huo et al. [112] studied the binding of protein to a charged microgel and the influence of protein on the physical appearance and structural peculiarities of the microgel. For this purpose, pH- and temperature-sensitive poly(A-isopropylacrylamide-co-acrylic acid) [P(NIPA-co-AAc)] microgels with various... 

Xu H, Xu 1, Zhu Y, Liu H, Liu S (2006) In situ formation of silver nanoparticles with tunable spatial distribution at the poly(A-isopropylacrylamide) corona of unimolecular micelles. Macromolecules 39 8451-8455... 

Pelton RH (1988) Polystyrene and polystyrene-butadiene latexes stabilized by poly(A-isopropylacrylamide). J Polym Sci 26 9-18... 

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