Hydrogels molecularly imprinted

Hydrogels are used as molecular imprinting matrix for proteins for their loose networks enabling the diffusion of the protein and for their aqueous environment and thus compatibility with biomacromolecules [106, 107]. If the MIP precursors mixture contains a very low concentration of monomers, nanometer-sized microgels are sometimes formed upon polymerization rather than macrogels. In order to generate... 

X. C. Liu and J. S. Dordick, Sugar acrylate-based polymers as chiral molecularly imprintable hydrogels, 1. Polym. Sci., Part A Polym. Chem., 37 (1999) 1665-1671. 

Molecularly Imprinted Materials Hydrogels are insoluble, cross-linked networks of hydrophilic homo- or heterocopolymers, with the ability to take up... 

Parmpi P, Kofinas P. Biomimetic glucose recognition using molecularly imprinted polymer hydrogels. Biomaterials 2004, 25, 1969-1973. 

Byrne ME, Park K, Peppas NA. Molecular imprinting within hydrogels. Advanced Drug Delivery Reviews 2002, 54, 149-161. 

Wizeman WJ, Kofinas P. Molecularly imprinted polymer hydrogels displaying isomerically resolved glucose binding. Biomaterials 2001, 22, 1485-1491. 

In contrast to these approaches based on nonspecific interactions, Zhang and coworkers described a molecularly imprinted hydrogel based on the ther-moresponsive PNIPAM [184], This hydrogel was prepared by copolymerization of a metal chelate monomer iV-(4-vinyl)-benzyl iminodiacetic acid, which formed a coordination complex with the template protein in the presence of Cu ions, A-isopropylacrylamide, acrylamide, and IV.lV-methylenebisacrylamide as crosslinker. The interaction of the imprinted thermoresponsive hydrogel with the protein could be switched between coordination effects and electrostatic attraction by addition or omission of Cu ions. Furthermore, this imprinted hydrogel allowed switching of lysozyme adsorption by changing the temperature. 

Alvarez-Lorenzo et al. demonstrated that molecularly imprinted hydrogel CLs, even slightly cross-Unked (0.32-8.34 mol%), showed a 9- to 20-fold higher adsorption affinity for the template drug, timolol, than the corresponding non-imprinted lenses. ... 

Ali, M. Byrne, M.E. Controlled release of high molecular weight hyaluronic acid from molecularly imprinted hydrogel contact lenses. Pharm. Res. 2009, 26 (3), 714-726. 

Malaekeh-Nikouei, B. Abbasi Ghaeni, F. Motamedshariaty, V.S. Mohajeri, S.A. Controlled release of prednisolone acetate from molecularly imprinted hydrogel contact lenses. J. Appl. Polym. Sci. 2012,126 (1), 387-394. 

Abbate, V., Frascione, N., Bansal, S. S. (2010). Preparation, characterization, and binding profile of molecularly imprinted hydrogels for the peptide henddin. I. Polvm. Sci. Part A Polvm. Chem.. 48,1721-1731. 

Gong, C., Wong, K., Lam, M. H. (2008]. Photoresponsive molecularly imprinted hydrogels for the photoregulated release and uptake of pharmaceuticals in the aqueous media, OienLjtQ., 20,1353-1358. 

Liu, X.-C. Dordick, J.S. Sugar acrylate-based pol5mers as chiral molecularly imprint-able hydrogels. J. Polym. Sci. Polym. Chem. 1999, 37, 1665-1671. 

Karmalkar, R.N. Kulkarni, M.G. Mashelkar, R.A. Molecularly imprinted hydrogels exhibit chymotrypsin-like activity. Macromolecules 1996, 29, 1366-1368. 

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