7V-Cyclohexyl-

Chlorophenoxy)phenyl)-l,l-dimethylurea, see Chloroxuron 7V -(4-(4-Chlorophenoxy)phenyl)-7V,7V-dimethylurea, see Chloroxuron 1 -(4-Chlorophenoxy)-3,3 -(1,2,4-triazol- l-yl)butan-2-one, see Triadimefon 7V-(((4-Chlorophenyl)ainino)carbonyl)-2,6-difluorobenzamide, see Diflubenzuron (3-Chlorophenyl)carbamic acid 1-methylethyl ester, see Chlorpropham tran5-5-(4-Chlorophenyl)-7V-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxainide, see Hexythiazox... 

The procedure has been extended to the synthesis of 7V,7V -substituted diamines 166 from the diazides 164 and dichloroboranes 165177. Primary amines protected by the t-butoxycarbonyl group are obtained by the action of trialkylboranes R3B (R = Bu, s-Bu, CsHn or cyclohexyl) on the lithium or potassium salt of t-butyl 7V-(tosyloxy)carbamate (equation 62)178. 

The conversion of symmetrical into unsymmetrical thioureas is exemplified by the formation of Af-cyclohexyl-Af -phenylthiourea when yV,iV-diphenyl thiourea is heated with cyclohexylamine and triethylamine in acetonitrile367. Carbonylation of lithium piperidide in the presence of tellurium generates the lithium carbamotellurate 307, which is trapped as the 7V-ethyl carbamotellurate 308 by ethyl bromide368. 

Reaction of carbon disulfide with N,7V -dialkylethylenediamines, RNHCH2CH2NHR, gives -y-alkylaminodithiocarbamic acids 183, the zwitterions of which can be oxidized with iodine/potassium iodide in alkali to yield 1,2,5-thiadiazines 184 (R = Et, i-Pr, cyclohexyl) (49JOC946 50USP2514200 51USP2537633). 

The a-cyanoenamine 21, which exists as a mixture of E- and Z-isomers, is deproto-nated by lithium diisopropylamide to give the stabilized 7V,7V-(dimethylamino)allyl anion 22. This reacts with aldehydes RCHO (R = Ph, Ar or cyclohexyl) to afford products which are readily transformed into y-lactones by the action of dilute hydrochloric acid (equation 15)34. 

In a systematic study of the addition of cyclohexyl radicals to a-substi-tuted methyl acrylates, Giese (1983) has shown that the captodative-substituted example fits the linear correlation line of log kTCl with o-values as perfectly as the other cases studied. Thus, no special character of the captodative-substituted olefin is displayed. More recently, arylthiyl radicals have been added to disubstituted olefins in order to uncover a captodative effect in the rate data (Ito et al., 1988). Even though a-7V,iV-dimethyl-aminoacrylonitrile reacts fastest in these additions, this observation cannot per se be interpreted as the manifestation of a captodative effect. Owing to the lack of rate data for the corresponding dicaptor- and didonor-substituted olefins, it is not possible to postulate a special captodative effect. The result confirms only that the A.jV-dimethylamino-group, as expected from its c -value, enhances the addition rate. In the sequence a-alkoxy-, a-chloro-, a-acetoxy- and a-methyl-substituted acrylonitriles, it reacts fastest. 

The reactions of 2,3-diphenylcyclopropenone with 7V-sulfinylarylamines in the presence of tet-racarbonylnickel gave pyrrole-2,5-diones 19. In contrast with these results, the reaction with A -sulfinylcyclohexylamine gave a 1 1 cycloadduct, 2-cyclohexyl-4,5-diphenylisothiazole-l,3-dione in 36% yield. ... 

Reaction of 7V-ethoxycarbonyl-A( ,5-dimethylisothiourea with cyclohexyl isocyanate at room temperature gave the l,3,5-triazine-2,4(l//,3//)-dione (162) in 78% yield (Equation (28)) <85JAP60166672>. 7V-Methoxycarbonyl-0-methylisoureas (163) also react with isocyanates, and the intermediate (163) can be cyclized in methoxide/methanol at reflux temperature to the 1,3,5-triazine-... 

V-Cyclohexylthiobenzamide 509 Cyclohexyl isothiocyanate (10.89 g, 0.077 mole) in ether (50 ml) is added with stirring to phenylmagnesium bromide (0.08 mole) in ether (200 ml) at 5°. Stirring is continued for a further hour at 5°, then the solution is allowed to warm gradually to room temperature and poured on ice. The mixture is acidified and the ethereal layer is dried over sodium sulfate and evaporated. The solid residue (15 g, 88%) is recrystallized several times from light petroleum, then melting at 90-92°. 

Further, formation of quaternary salts can interfere in the ready removal of hydrogen halide by tertiary amines such as dimethylaniline, pyridine, or quinoline.58 To overcome this, Hiinig and Kiessel59 successfully applied sterically hindered tertiary amines, e.g., ethyldiisopropylamine and 7V-ethyldi-(cyclohexyl)amine for instance, removing hydrogen bromide from 1,2-di-bromo-2-methylpropane by potassium hydroxide in ethylene glycol60 gave unsatisfactory yields of l-bromo-2-methyl-l-propene ... 

The most important complex of this type is [Rh(NO)Cl2(PPh3)2], which was first prepared in 1962. The tri(cyclohexyl)phosphine and triphenylarsine analogs were also prepared at this date. The dichloro complexes were precipitated when excess neutral ligand was allowed to react with [Rh(NO)2Cl] ,. The preparative routes available for [Rh(NO)Cl2(PPh3)2] are summarized in Scheme 43. Again lV-methyl-7V-nitrosotoluene-p-sulfonamide is the most convenient source of the nitrosyl ligand. - ... 

Ishida and Chono describe similar reactions over M0O3 or WO3 supported on silica. Thus, an n-vtderonitrile yield of 73% was obtained with a selectivity of 84% over MoOs/SiOa at 703 K. Similarly, 7V-hexylformamide, formanilide, A7-cyclohexyl-formamide, A, 7V -hexamethyleneformamide and Af-benzylformamide gave nitriles in 50 — 80% selectivity. 

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