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Zyvox - Linezolid

The author and a co-worker later exploited 3 mm NMR probe capabilities in a study of the thermal degradation products of the oxazolidinone antibiotic Zyvox (linezolid, 41) based on the use of H-15N heteronuclear shift correlation experiments.127 In a study of the structure-function relationships of a new growth hormone-releasing peptide, ghrelin, Bednarek and co-workers128 at Merck utilized micro-probe capabilities in the characterization of the structures of the minimum sequence of ghrelin necessary for activity. As a result of these efforts, a small spiroindan, MK-0677 (59) with oral bioavailability was found to be one of the most potent synthetic analogs with this activity. [Pg.54]

Zyvox (Linezolid) Fliarmacia Ltd UK Summary of product characteristics, July 2007. [Pg.313]

Linezolid (Zyvox) is the first of a new classification, an oxazolidinone, that acts by bindingto a site on a specific ribosomal RNA and preventing the formation of a component necessary for the bacteria to replicate It is... [Pg.101]

Linezohd (Zyvox) is an oxazolidinone, a tive-membered heterocychc ring that forms the core of the hnezohd structure. The approval of hnezohd by the FDA in 2000 marked the first new structural class of antibacterial introduced into medical practice in the United States in 40 years. It is notable for its activity against methicillin-resistant Staph aureus, MRSA, and vancomycin-resistant Enterococcus faecium, VRE. It is bacteriostatic rather than bactericidal but finds significant use in patients with an intact immune system. Like several other classes of antibacterials, linezolid is an inhibitor of protein synthesis. It interacts specifically with the RNA component of a bacterial ribosome subunit to prevent initiation of protein synthesis. [Pg.328]

Aztreonam (Azactam) Clindamycin (Cleocin, Cleocin-T, others) Fosfomycin (Monurol) Linezolid (Zyvox) Metronidazole (Flagyl, MetroGel)... [Pg.36]

Linezolid (Zyvox) Used as a last generation against gram-... [Pg.38]

Zyvox for oral suspension is supplied as an orange-flavored granule/powder for constitution into a suspension for oral administration. Following constitution, each 5 mL contains 100 mg of linezolid. Inactive ingredients are... [Pg.142]

Chapter 7. Antibacterials Ciprofloxacin (Cipro ), and Linezolid (Zyvox )... [Pg.75]

USAN- Linezolid Trade Name Zyvox Pharmacia Launched 2000 M.W. 337.35... [Pg.75]

The remarkable capacity of S. aureus to develop resistance to antibiotics is no more clearly illustrated than its recently reported success against linezolid (Zyvox ). Linezoid is the first entirely new type of antibiotic (oxazolidinones) introduced in 35 years. The FDA approved it in April 2000 for the treatment of several infections including resistant strains of S. aureus. Flowever, it took only slightly more than a year for resistance to manifest itself. In the summer of 2001, the first report of staph resistance to the new antibiotic was observed in an 85-year-old man undergoing dialysis. [Pg.170]

Linezolid (Zyvox ) Pharmacia/Pfizer Antibacterial agent Launched 2000... [Pg.198]

See other pages where Zyvox - Linezolid is mentioned: [Pg.232]    [Pg.232]    [Pg.1178]    [Pg.1392]    [Pg.1346]    [Pg.1390]    [Pg.232]    [Pg.232]    [Pg.1178]    [Pg.1392]    [Pg.1346]    [Pg.1390]    [Pg.101]    [Pg.207]    [Pg.343]    [Pg.1016]    [Pg.83]    [Pg.229]    [Pg.509]    [Pg.1070]    [Pg.198]    [Pg.420]   


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