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Zolpidem overdose

Two deaths due to acute intentional zolpidem overdose have been reported (43). [Pg.447]

The cause of death in both cases was thought to have been acute zolpidem overdose, but it is not clear how risperidone and carbamazepine could have been excluded as possible contributors. [Pg.447]

Gock SB, Wong SH, Nuwayhid N, Venuti SE, Kelley PD, Teggatz JR, Jentzen JM. Acute zolpidem overdose—report of two cases. J Anal Toxicol 1999 23(6) 559-62. [Pg.449]

Hamad A, Sharma N. Acute zolpidem overdose leading to coma and respiratory failure. Intensive Care Med 2001 27(7) 1239. [Pg.449]

Both zolpidem and zaleplon appear to be nonfatal in overdose. However, overdoses in combination with other central nervous system (CNS) depressant agents pose a greater risk. Recommended treatment consists of general symptomatic and supportive measures, including gastric lavage. Use of flumazenil may be helpful. [Pg.77]

More recently, non-BZD anxiolytics, such as buspirone, and nonbarbiturate, non-BZD hypnotics, such as zolpidem and zaleplon, have been developed. The more recent anxiolytics and hypnotics offer equal efficacy, fewer serious adverse effects, and less risk of a fatal consequence due to accidental or intentional overdose. Unfortunately, these compounds have not entirely eliminated the hazards of tolerance, dependency, and withdrawal syndromes, although they do have a lower abuse potential than their predecessors. [Pg.229]

Lheureux P, Debailleul G, De Witte O, Askenasi R. Zolpidem intoxication mimicking narcotic overdose response to flumazenil. Hum Exp Toxicol 1990 9(2) 105-7. [Pg.448]

Physical examination revealed tachycardia with irregular heart rate, shallow respiration, decreased bowel sounds, dilated pupils, and hypertheimia. An ECG revealed a widened QRS complex with diffuse T wave changes. If this patient had taken a drug overdose the most likely causative agent was (A) Clozapine Fluoxetine Lithium Thioridazine Zolpidem... [Pg.578]

The drug class of benzodiazepines includes many compounds that vary widely in po-tenoy, duration of effect, presence or absence of active metabolites, and clinical use (Table 11-14). Two nonbenzodiazepines, zolpidem and zaleplon, have similar effects and are included here. In general, death from benzodiazepine overdose is rare, unless the drugs are combined with other CNS-depressant agents such as ethanol or barbiturates. Newer potent, short-acting agents have been considered the sole cause of death in recent forensic cases. [Pg.129]

Flumazenil is a benzodiazepine antagonist used to reverse the effects of benzodiazepines in the treatment of poisoning or in anesthesia [46 , 47, 48, 49 ]. It reduces the risks of complications from drug overdose, obviating the need for invasive interventions such as mechanical ventilation and invasive hemodynamic monitoring [5(E]. However, it is not effective in reversing the amnesic effects of midazolam [51 ]. It has also been used to reverse the effects of zaleplon [52 J, zolpidem [53, 54, 55 ], zopiclone [56", 57" ], antihistamines such as promethazine [58, 59 ], baclofen... [Pg.80]


See other pages where Zolpidem overdose is mentioned: [Pg.131]    [Pg.822]    [Pg.131]    [Pg.822]    [Pg.112]    [Pg.669]    [Pg.484]    [Pg.304]    [Pg.443]    [Pg.449]    [Pg.3723]    [Pg.3730]    [Pg.1494]    [Pg.277]    [Pg.1494]    [Pg.97]   
See also in sourсe #XX -- [ Pg.77 ]




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